74839-84-2

Usage

Uses

Used in Pharmaceutical Synthesis:
(2R,3R)-(+)-BIS(DIPHENYLPHOSPHINO)BUTANE is used as a reagent for the synthesis of endothelin A receptor antagonists, which are important in the treatment of various cardiovascular and cerebrovascular diseases. Its chiral nature allows for the selective synthesis of these compounds, contributing to the development of more effective medications.
Used in Synthesis of (R)-Tolterodine and (S)-Tolterodine:
In the pharmaceutical industry, (2R,3R)-(+)-BIS(DIPHENYLPHOSPHINO)BUTANE is utilized as a key reagent in the synthesis of (R)-Tolterodine and (S)-Tolterodine. These compounds are used as active ingredients in medications for treating overactive bladder and urinary incontinence, providing relief to patients suffering from these conditions.
Chemical Properties:
As a white crystalline powder, (2R,3R)-(+)-BIS(DIPHENYLPHOSPHINO)BUTANE exhibits distinct chemical properties that make it suitable for use in various chemical reactions and processes. Its diphenylphosphino groups contribute to its reactivity and selectivity, making it a preferred choice for specific applications in the pharmaceutical industry.

Purification Methods

It recrystallises from absolute EtOH (~6g in 60mL) as colourless plates [Fryzuk & Bosnich J Am Chem Soc 99 6262 1977, Fryzuk & Bosnich J Am Chem Soc 101 3043 1979].

InChI:InChI=1/C28H28P2/c1-23(29(25-15-7-3-8-16-25)26-17-9-4-10-18-26)24(2)30(27-19-11-5-12-20-27)28-21-13-6-14-22-28/h3-24H,1-2H3/t23-,24-/m1/s1

Upstream product

• 192449-15-3 (R,R)-2,3-Bis(diphenylphosphinoyl)butane 
• 74839-83-1 (2S,3S)-bis(4-methylbenzenesulfonyl)butane 
• 65567-06-8 lithium diphenylphosphide 
• 1079-66-9 chloro-diphenylphosphine 
• 113017-77-9 2,3-dibuta-1,3-diene 

Relevant academic research and scientific papers

Highly Active and Selective Ethylene Oligomerization Catalyst and Method of Preparing Hexene or Octene Using the Same

This invention relates to a chromium complex compound for selective ethylene oligomerization including a chiral ligand, and to a method of selectively preparing 1-hexene or 1-octene from ethylene using the same.

Ethylene oligomerization catalyst systems having enhanced selectivity

Disclosed herein is a catalyst system for selective oligomerization of ethylene, which comprises a P—C—C—P frame-work ligand, which is (R1)(R2)P—(R5)CHCH(R6)—P(R3)(R4), and a chromium-based metal compound. Also disclosed is a method of greatly enhancing the activity and selectivity of oligomerization, such as trimerization or tetramerization, using a ligand having a specific steric arrangement structure.

Synthesis of the chiral diphosphine ligand 2,3-bis(diphenylphosphino)butane (CHIRAPHOS)

A new synthesis of CHIRAPHOS starting from readily available 2,3-bis(diphenylphosphinyl)- 1,3-butadiene has been devised. The key step of the synthesis is the hydrogenation of the diene to rac-2,3-bis(diphenylphosphinyl)butane. This reduction can be conve

A New Chiral Rhodium(I) Complex of (2R,3R)-2,3-Bis(diphenylphosphino)butane for Asymmetric Hydrogenations

Rhodium(I) complexes of the new chiral ligand (2R,3R)-2,3-bis(diphenylphosphino)butane (4) - which is easily prepared from natural tartaric acid - hydrogenate α-(acylamino)acrylic acids to natural (S)-acylamino acids in high chemical (95-100percent) and optical (80-100percent) yields.