192512-81-5

Basic information

• Product Name: (R)-3-(4-methylphenyl)butanenitrile
• Synonyms: (R)-3-(4-methylphenyl)butanenitrile
• CAS NO: 192512-81-5
• Molecular Weight: 159.231
• Mol File: 192512-81-5.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: (R)-3-(4-methylphenyl)butanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-(4-methylphenyl)butanenitrile(192512-81-5)
• EPA Substance Registry System: (R)-3-(4-methylphenyl)butanenitrile(192512-81-5)

Safety Data

• Hazardous Substances Data: 192512-81-5(Hazardous Substances Data)

Upstream product

• 4371-50-0 para-cymen-9-ol 
• 1197-01-9 p-cymene-8-ol 
• 1195-32-0 1-methyl-4-isopropenylbenzene 
• 773837-37-9 sodium cyanide 
• 23430-44-6 (S)-2-(4-methylphenyl)-1-propyl p-toluenesulfonate 
• 35675-44-6 4-methylphenylacetyl chloride 
• 93922-51-1 (S)-2-(4-methylphenyl)-1-propanol 
• 622-47-9 4-tolylacetic acid 
• 848674-80-6 (4S,2'S)-4-benzyl-3-[(4-methylphenyl)-2-propanoyl]-2-oxazolidinone 
• 848674-79-3 (S)-4-benzyl-3-(4-methylphenylacetyl)-2-oxazolidinone 
• 122-00-9 para-methylacetophenone 
• 130240-32-3 (E)-3-(p-tolyl)-2-butenenitrile 
• 143-33-9 sodium cyanide 
• 151-50-8 potassium cyanide 

Downstream Products

• 192513-04-5 1-((R)-3-Benzenesulfonyl-1-methyl-cyclopent-2-enyl)-4-methyl-benzene 
• 192766-60-2 Trimethyl-((R)-5-p-tolyl-hex-1-ynyl)-silane 
• 192513-08-9 1-Methyl-4-((R)-1-methyl-cyclopent-2-enyl)-benzene 
• 106035-79-4 (R)-3-(4-methylphenyl)-1-butanol 
• 101693-57-6 (R)-(+)-4-methyl-4-(4-methylphenyl)cyclopent-2-enone 
• 72843-32-4 1-((R)-3-Bromo-1-methyl-propyl)-4-methyl-benzene 
• 848674-84-0 (R)-N-methyl-N-methoxy-3-(4-methylphenyl)butanamide 
• 1141-54-4 (R)-2-methyl-6-(4-methylphenyl)-2-hepten-4-one 
• 93922-52-2 (R)-3-(4-methylphenyl)butanoic acid 
• 104598-15-4 (R)-3-(4-methylphenyl)butanal 

Relevant articles and documents

Lipase-mediated resolution of substituted 2-aryl-propanols: Application to the enantioselective synthesis of phenolic sesquiterpenes

A comprehensive study of the lipase-mediated resolution of substituted 2-aryl-propanols is reported. The latter alcohols were submitted to the irreversible acetylation catalyzed either by PPL, CRL, or lipase PS. The enantioselectivity of these transformations was dependent on the type of lipase used. The type of substituents and particularly their position on the aromatic ring strongly affected the selectivity of the reaction. The experiments described prove that PPL is the more versatile lipase catalyzing the acetylation with an enantiomeric ratio (E) value that ranges from 1 up to 144, depending on the substrate used. Conversely, the same transformations were catalyzed by CRL and lipase PS with an enantiomeric ratio value, which is always less than 5. The remarkable behavior of PPL was exploited in the large scale resolution of some substituted 2-aryl-propanols whose enantiomeric forms are relevant building blocks in the enantioselective synthesis of phenolic sesquiterpenes. By these means, the synthesis of (S)-turmeronol B and the formal syntheses of (R)-curcumene, (R)-curcuphenol, (R)-xanthorrhizol, and (R)-curcuhydroquinone were accomplished.

Highly enantioselective conjugate reduction of β,β-disubstituted α,β-unsaturated nitriles

(Chemical Equation Presented) Easy access: The highly enantioselective conjugate reduction of α,β-unsaturated nitriles is achieved by employing bench-top stable copper(II) acetate and josiphos (L) as the ligand in the presence of polymethylhydrosiloxane (

Organic synthesis in pheromone science

Examples are given to illustrate the use of chemical and/or enzymatic asymmetric reactions in the synthesis of the new pheromones of the broad-horned flour beetle, flea beetle, currant stem girdler and Colorado potato beetle. The relationships between ste