192571-92-9Relevant academic research and scientific papers
Total synthesis of antibiotic karnamicin B1
Umemura, Kazuyuki,Watanabe, Koichi,Ono, Kazumasa,Yamaura, Masanori,Yoshimura, Juji
, p. 4811 - 4814 (1997)
The novel antifungal karnamicin B1 (1), 5-hydroxy-3,4-dimethoxy-2-{2-(4-oxopentyl)-4-thiazolyl}pyridine-6-carboxamide was first synthesized via the formation of partially methylated trihydroxy pyridine by ring-transformation from the corresponding furan derivative and subsequent regioselective introduction of 2,6-substituents using Meisenheimer-type reaction.
