
Tetrahedron Letters p. 4811 - 4814 (1997)
Update date:2022-07-31
Topics:
Umemura, Kazuyuki
Watanabe, Koichi
Ono, Kazumasa
Yamaura, Masanori
Yoshimura, Juji
The novel antifungal karnamicin B1 (1), 5-hydroxy-3,4-dimethoxy-2-{2-(4-oxopentyl)-4-thiazolyl}pyridine-6-carboxamide was first synthesized via the formation of partially methylated trihydroxy pyridine by ring-transformation from the corresponding furan derivative and subsequent regioselective introduction of 2,6-substituents using Meisenheimer-type reaction.
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