192587-18-1 Usage
Uses
Used in Oncology:
2,4-Diamino-6-(p-methoxyphenyl)pteridine hydrochloride is used as an anti-cancer agent for the treatment of various types of cancer. It targets the enzyme dihydrofolate reductase, thereby inhibiting the synthesis of essential cellular components like DNA, RNA, and proteins, which are necessary for the growth and division of cancer cells.
Used in Autoimmune Diseases:
2,4-Diamino-6-(p-methoxyphenyl)pteridine hydrochloride is used as an immunosuppressive agent in the management of autoimmune diseases. By suppressing the immune system, it helps to reduce the severity of symptoms and the progression of the disease.
Used in Inflammatory Conditions:
2,4-Diamino-6-(p-methoxyphenyl)pteridine hydrochloride is used as an anti-inflammatory agent for the treatment of severe inflammatory conditions. Its immunosuppressive properties help to alleviate inflammation and associated symptoms.
Used in Pharmaceutical Formulations:
2,4-Diamino-6-(p-methoxyphenyl)pteridine hydrochloride is used as an active pharmaceutical ingredient in various formulations, such as tablets, injections, and oral solutions, to ensure effective delivery and administration of the drug to patients under the guidance of healthcare professionals.
Check Digit Verification of cas no
The CAS Registry Mumber 192587-18-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,2,5,8 and 7 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 192587-18:
(8*1)+(7*9)+(6*2)+(5*5)+(4*8)+(3*7)+(2*1)+(1*8)=171
171 % 10 = 1
So 192587-18-1 is a valid CAS Registry Number.
192587-18-1Relevant academic research and scientific papers
Immunosuppressive effects of pteridine derivatives
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Page 26, (2008/06/13)
This invention relates to a group of trisubstituted and tetrasubstituted pteridine derivatives, their pharmaceutically acceptable salts, N-oxides, solvates, dihydro- and tetrahydroderivatives and enantiomers, possessing unexpectedly desirable pharmaceutical properties, in particular which are highly active immunosuppressive agents, and as such are useful in the treatment in transplant rejection and/or in the treatment of certain inflammatory diseases. These compounds are also useful in preventing or treating cardiovascular disorders, allergic conditions, disorders of the central nervous system and cell proliferative disorders.
Inhibition of neuronal nitric oxide synthase by 4-amino pteridine derivatives: Structure-activity relationship of antagonists of (6R)-5,6,7,8- tetrahydrobiopterin cofactor
Fr?hlich, Lothar G.,Kotsonis, Peter,Traub, Hermann,Taghavi-Moghadam, Shahriyar,Al-Masoudi, Najim,Hofmann, Heinrich,Strobel, Hartmut,Matter, Hans,Pfleiderer, Wolfgang,Schmidt, Harald H. H. W.
, p. 4108 - 4121 (2007/10/03)
The family of nitric oxide synthases (NOS) catalyzes the conversion of L-arginine to L-citrulline and nitric oxide (NO), an important cellular messenger molecule which has been implicated in the pathophysiology of septic shock and inflammatory and neurode
