19259-05-3Relevant academic research and scientific papers
Co-thermolysis: A one-pot synthetic method for novel 2-substituted-5- (trifluoromethoxy)thiophenes
Peláez,Argüello
scheme or table, p. 5242 - 5245 (2010/11/03)
A new 'green' process to obtain trifluoromethoxylated compounds by a gas-phase method has been accomplished. Through it, new 2-substituted-5- (trifluoromethoxy)thiophenes have been obtained in moderate to good yields. Though the reaction occurs in the gas-phase and radicals are involved, an electron transfer mechanism is also postulated to explain the appearance of all detected products.
Selective metallation of 3-halothiophenes: Practical methods for the synthesis of 2-bromo-3-formylthiophene
Sonoda, Motohiro,Kinoshita, Shoko,Luu, Thanh,Fukuda, Hiroshi,Miki, Koji,Umeda, Rui,Tobe, Yoshito
experimental part, p. 3315 - 3323 (2011/03/20)
Selective lithiation of 3-bromothiophene was accomplished under controlled conditions without formation of undesired thienyllithium compounds. A thienyl Grignard reagent derived from 2-bromo-3-iodothiophene was transformed into 2-bromo-3-formylthiophene in high selectivity by formylation with dimethylformamide (DMF) at optimal reaction temperature. Copyright Taylor & Francis Group, LLC.
