192644-24-9

Upstream product

• 192644-21-6 (3,5-dimethylphenyl)-(2-methylcyclopropyl)methanone 
• 192644-22-7 2-[3-(2-amino-1-methylethyl)-2-(3,5-dimethylphenyl)-1H-indol-5-yl]-2-methylpropionic acid ethyl ester 
• 501-53-1 benzyl chloroformate 
• 192644-23-8 2-{2-(3,5-dimethylphenyl)-3-[1-methyl-2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indol-5-yl}-2-methylpropionic acid ethyl ester 

Downstream Products

• 376364-26-0 {2-[5-(1-diethylcarbamoyl-1-methyl-ethyl)-2-(3,5-dimethyl-phenyl)-1H-indol-3-yl]-propyl}-(4-pyridin-4-yl-butyl)-carbamic acid benzyl ester 
• 192644-25-0 2-[3-{2-[benzyloxycarbonyl-(4-pyridin-4-yl-butyl)-amino]-1-methyl-ethyl}-2-(3,5-dimethyl-phenyl)-1H-indol-5-yl]-2-methyl-propionic acid 

Relevant academic research and scientific papers

Synthesis of chiral β-methyl tryptamine-derived GnRH antagonists

The stereospecific formation of 2-aryl-β-methyl tryptamine derivatives 15 and 16 from chiral 4-chloro-1-(3,5-dimethylphenyl)-3-methylbutanones is described. These intermediates were further manipulated into the GnRH antagonists 1b and 1c in five steps.

Antagonists of gonadotropin releasing hormone

There are disclosed compounds of formula (I) and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.

ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE

There are disclosed compounds of formula (I) STR1 and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.