192644-25-0

Upstream product

• 192644-24-9 2-[3-{2-[benzyloxycarbonyl-(4-pyridin-4-yl-butyl)-amino]-1-methyl-Ethyl}-2-(3,5-dimethylphenyl)-1H-indol-5-yl]-2-methylpropionic acid ethyl ester 
• 192644-23-8 2-{2-(3,5-dimethylphenyl)-3-[1-methyl-2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indol-5-yl}-2-methylpropionic acid ethyl ester 
• 192644-22-7 2-[3-(2-amino-1-methylethyl)-2-(3,5-dimethylphenyl)-1H-indol-5-yl]-2-methylpropionic acid ethyl ester 
• 192644-21-6 (3,5-dimethylphenyl)-(2-methylcyclopropyl)methanone 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 376364-26-0 {2-[5-(1-diethylcarbamoyl-1-methyl-ethyl)-2-(3,5-dimethyl-phenyl)-1H-indol-3-yl]-propyl}-(4-pyridin-4-yl-butyl)-carbamic acid benzyl ester 

Relevant academic research and scientific papers

Synthesis of chiral β-methyl tryptamine-derived GnRH antagonists

The stereospecific formation of 2-aryl-β-methyl tryptamine derivatives 15 and 16 from chiral 4-chloro-1-(3,5-dimethylphenyl)-3-methylbutanones is described. These intermediates were further manipulated into the GnRH antagonists 1b and 1c in five steps.