192648-66-1 Usage
General Description
The chemical "8-Azabicyclo[3.2.1]octane-2-carboxylic acid, 3-[[2-(acetyloxy)benzoyl]oxy]-8-methyl-, methyl ester, (1R,2R,3S,5S)-" is a complex compound with a molecular formula of C21H23NO5. It is a methyl ester derivative of 8-azabicyclo[3.2.1]octane-2-carboxylic acid, and its structure incorporates an acetyloxybenzoyl group. This chemical compound is classified as a chiral molecule, with a specific 1R,2R,3S,5S stereochemistry. The compound has potential applications in the field of medicinal chemistry and pharmaceuticals, where it may be utilized as a building block for drug development and synthesis. Further research and analysis may be necessary to fully understand its properties and potential uses.
Check Digit Verification of cas no
The CAS Registry Mumber 192648-66-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,2,6,4 and 8 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 192648-66:
(8*1)+(7*9)+(6*2)+(5*6)+(4*4)+(3*8)+(2*6)+(1*6)=171
171 % 10 = 1
So 192648-66-1 is a valid CAS Registry Number.
192648-66-1Relevant articles and documents
Synthesis and dopamine transporter binding of 2'-substituted cocaine analogs
El-Moselhy, Tarek F.,Avor, Kwasi S.,Basmadjian, Garo P.
, p. 50 - 57 (2007/10/03)
A series of 2'-substituted cocaine analogs (4-8) was synthesized and evaluated in an in vitro dopamine transporter (DAT) system. Compounds 4-7 were prepared by esterifying the 3β-hydroxyl group of ecgonine methyl ester (3) using the appropriate acid chloride in the presence of NEt3 and benzene. Compound 3 was obtained from cocaine (1) by hydrolysis using lN HCl to afford ecgonine HCl which was subjected to acid catalyzed esterification using MeOH saturated with HCl gas. Compound 8 was obtained from 5 by selective trans- esterification with MeOH and HCl gas. The binding affinities of these compounds were determined at DAT for the displacement of [3H]WIN-35428 (2). The 2'-substituted acetoxy and hydroxy analogs exhibited high binding potency for the DAT compared to cocaine (3.5- and 10-fold respectively).
