192702-71-9Relevant academic research and scientific papers
ATF6 MODULATORS AND USES THEREOF
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Paragraph 178; 179, (2021/04/17)
Compounds (I) as modulators of Activating Transcription Factor 6 (ATF6) are provided. The compounds may find use as therapeutic agents for the treatment of diseases or disorders mediated by ATF6 and may find particular use in the treatment of viral infections, neurodegenerative diseases, vascular diseases, or cancer.
Catalytic enantioselective Negishi reactions of racemic secondary benzylic halides
Arp, Forrest O.,Fu, Gregory C.
, p. 10482 - 10483 (2007/10/03)
This report describes the first enantioselective cross-couplings of racemic secondary benzylic halides, specifically, nickel-catalyzed Negishi reactions of bromides and chlorides. The catalyst components are commercially available and air-stable, and the reaction is not highly oxygen- or moisture-sensitive (it can be set up in the air). The method has been applied to the catalytic enantioselective synthesis of intermediates employed by others in the generation of bioactive compounds (e.g., trikentrin A and an androgen receptor agonist). Copyright
