192724-31-5Relevant academic research and scientific papers
Synthesis of the spirochroman core of dihypoestoxide and stereochemical proposal for the natural product
Uroos, Maliha,Hayes, Christopher J.
supporting information; experimental part, p. 5294 - 5297 (2011/02/22)
The tricyclic spirochroman core of dihypoestoxide has been synthesized from geranoic acid in seven steps using a hetero-Diels-Alder cycloaddition as a key step, thus providing support for the proposed biosynthesis of the natural product. Furthermore, analysis of the 13C NMR data obtained for all four diastereoisomers of the synthetic spirochroman core has allowed us to propose a full stereochemical assignment for dihypoestoxide.
