19275-56-0Relevant academic research and scientific papers
Tetrahydrocarbazoles by mechanochemical Fischer indolisation
Qiu, Yichen,Puni, Kararaina Te,Duplan, Clotilde C.,Lindsay, Ashley C.,Sperry, Jonathan
, (2021)
The Fischer indolisation (FI) typically proceeds in the presence of a Br?nsted or Lewis acid in an organic solvent at elevated temperatures. Herein, we report that tetrahydrocarbazoles (THCs) are accessible by mechanochemical FI at ambient temperature. Using phenylhydrazine hydrochlorides in the presence of silica is critical for this solid-state variant of the FI.
