192765-48-3Relevant academic research and scientific papers
Synthesis of (S,5 Z,8 E,10 E)-12-hydroxyheptadeca-5,8,10-trienoic acid (12 S -HHT) and its analogues
Tojo, Toshifumi,Wang, Qian,Okuno, Toshiaki,Yokomizo, Takehiko,Kobayashi, Yuichi
, p. 1545 - 1548 (2013/08/23)
Natural 12S-HHT and its analogues were synthesized for study of structure and activity relationship toward the BLT2 receptor. The Suzuki-Miyaura coupling was used for construction of the 8E,10E-diene moiety of 12S-HHT and analogues of (12R)- and 12-keto-t
Addition of C-nucleophiles to carbohydrate-derived 2,3-dihydro-4H-pyran-4-ones: A new entry to thriomboxane analogues
Kirschning, Andreas,Harders, Jan
, p. 7867 - 7876 (2007/10/03)
Nucleophilic additions of silyl- and sulfur-stabilized carbanions 5a-e to carbohydrate-derived 2,3-dihydro-4H-pyran-4-ones 4a,b are described. Depending on the combination of substituents attached to the C1-anion, either 1,2- or 1,4-adducts are preferentially formed. Coupling of vinyl cuprate derived from 16 with enone 4a stereoselectively afforded pyranone 17 which is a potential precursor for thromboxane analogues.
