19278-85-4

Usage

Preparation

Obtained by reaction of chloroacetonitrile with 1,2,4-trimethoxybenzene (Hoesch reaction).

InChI:InChI=1/C11H13ClO4/c1-14-9-5-11(16-3)10(15-2)4-7(9)8(13)6-12/h4-5H,6H2,1-3H3

Upstream product

• 62957-60-2 2-ethoxyacetonitrile 
• 135-77-3 1,2,4-trimethoxy-benzene 
• 79-04-9 chloroacetyl chloride 

Downstream Products

• 41317-96-8 bis(2,4,5-trimethoxyphenacyl) disulfide 

Relevant academic research and scientific papers

A new efficient method for the preparation of intermediate aromatic ketones by Friedel–Crafts acylation

Abstract: As the most important method to prepare pharmaceutical and chemical intermediate aromatic ketones, Friedel–Crafts (F–C) acylation is used to seek a novel catalytic system which is imminently consistent with the concept of green chemistry. In this study, six deep eutectic solvents (DES) were synthesized for the Friedel–Crafts acylation reaction as a catalytic solvent. Among the six DES, choline chloride-zinc chloride ([ChCl][ZnCl2]2) proved to be the most competent candidate of electron-rich arenes with acylation reagent. It got the highest yield when 1.0 equivalent of [ChCl][ZnCl2]2 used with acyl halides at 70?°C. Recycled DES was reused directly without any extra process. After five cycles, the catalytic activity did not decrease significantly (80–85%). Finally, according to experimental validation, the possible mechanism of this reaction was considered. Graphical Abstract: [Figure not available: see fulltext.].