192820-78-3

Basic information

• Product Name: ES 936
• Synonyms: ES 936;5-Methoxy-1,2-dimethyl-3-[(4-nitrophenoxy)methyl]-1H-Indole-4,7-dione;5-methoxy-1,2-dimethyl-3-[(4-nitrophenoxy)methyl]indole-4,7-dione
• CAS NO: 192820-78-3
• Molecular Formula: C₁₈H₁₆N₂O₆
• Molecular Weight: 356.32944
• Mol File: 192820-78-3.mol
• Article Data: 1

Chemical Properties

• Melting Point: 227-288 °C
• Boiling Point: 623.9±55.0 °C(Predicted)
• Appearance: , orange to dark orange-red/
• Density: 1.38±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• Solubility: DMSO: soluble2mg/mL (clear solution, warmed)
• PKA: -11.69±0.40(Predicted)
• CAS DataBase Reference: ES 936(CAS DataBase Reference)
• NIST Chemistry Reference: ES 936(192820-78-3)
• EPA Substance Registry System: ES 936(192820-78-3)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 192820-78-3(Hazardous Substances Data)

Usage

Uses

ES 936 is a NAD(P)H:quinone oxidoreductase inhibitor.

Upstream product

• 100-02-7 4-nitro-phenol 
• 161518-24-7 3-(hydroxymethyl)-5-methoxy-1,2-dimethyl-1H-indole-4,7-dione 
• 205177-88-4 5-Methoxy-1,2-dimethyl-4,7-dioxo-4,7-dihydro-1H-indole-3-carboxylic acid ethyl ester 

Downstream Products

• 100-02-7 4-nitro-phenol 
• 161518-24-7 3-(hydroxymethyl)-5-methoxy-1,2-dimethyl-1H-indole-4,7-dione 

Relevant articles and documents

Indolequinone antitumor agents: Correlation between quinone structure, rate of metabolism by recombinant human NAD(P)H:quinone oxidoreductase, and in vitro cytotoxicity

A series of indolequinones bearing various functional groups has been synthesized, and the effects of substituents on the metabolism of the quinones by recombinant human NAD(P)H: quinone oxidoreductase (NQO1) were studied. Thus 5-methoxyindolequinones wer