192826-56-5Relevant academic research and scientific papers
Organocatalyzed Trifluoromethylation of Ketones and Sulfonyl Fluorides by Fluoroform under a Superbase System
Okusu, Satoshi,Hirano, Kazuki,Tokunaga, Etsuko,Shibata, Norio
, p. 581 - 585 (2015)
Fluoroform (HCF3, HFC-23) is a side product in the manufacture of polytetrafluoroethylene (Teflon). Despite its attractive properties, taming HCF3 for trifluoromethylation is quite problematic owing to its low acidity and the labilit
METHOD FOR PRODUCING TRIFLUOROMETHYL GROUP-CONTAINING ALCOHOLS
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Paragraph 0077; 0078; 0087; 0090, (2018/04/10)
PROBLEM TO BE SOLVED: To provide a method for producing trifluoromethyl group-containing alcohols useful as synthetic intermediates for medicines and agrochemicals. SOLUTION: This invention relates to a method for producing trifluoromethyl group-containing alcohols expressed by a formula (2), comprising: making carbonyl compounds expressed by a formula (1) react with trifluoromethane in an organic solvent in the presence of polyvalent ethers and potassium tert-butoxide, or kalium hexamethyldisilazide. (R1 and R2 are each independently a phenyl group etc.; R2 may combine with R1, to form a ring, and both R1 and R2 are not hydrogen atoms). SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT
METHOD FOR PRODUCING TRIFLUOROMETHYL GROUP-CONTAINING ALCOHOLS
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Paragraph 0029-0031; 0033-0035, (2017/02/02)
PROBLEM TO BE SOLVED: To provide a method for producing CF3 group-containing alcohols useful as production intermediates for medicines and agrochemicals. SOLUTION: The method for producing CF3 group-containing alcohols represented by formula (2) comprises
SOLVOLYTIC STUDIES OF THE HIGHLY CROWDED 1-ARYL-1-PHENYL-1-(TRIFLUOROMETHYL)METHYL BR0MIDE AND TOSYLATES
Liu, Kwang-Ting,Kuo, Mann-Yan
, p. 355 - 358 (2007/10/02)
In the titled system the remarkably high tosylate/bromide solvolysis rate ratio of 1.56E6:1 indicates a highly strained ground state, and the reverse order of reactivity for substrate having l-(4-trifluoromethyl)phenyl vs. that having 1-(3-trifluoromethyl
