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75-46-7 Usage

General Description

Trifluoromethane, also known as carbon trifluoride or methane, is a colorless and odorless gas with the chemical formula CHF3. It is a non-flammable, non-toxic, and extremely stable compound that is used primarily as a refrigerant in air conditioning and refrigeration systems due to its low boiling point and ozone-friendly properties. Trifluoromethane is also used as a propellant in aerosol sprays and as a cleaning agent in electronics manufacturing. It is considered to have low environmental impact and is classified as a greenhouse gas with a relatively low global warming potential compared to other hydrofluorocarbons. However, it is important to handle and store trifluoromethane with care, as it can displace oxygen and pose a risk of asphyxiation in poorly ventilated areas.

Check Digit Verification of cas no

The CAS Registry Mumber 75-46-7 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 7 and 5 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 75-46:
(4*7)+(3*5)+(2*4)+(1*6)=57
57 % 10 = 7
So 75-46-7 is a valid CAS Registry Number.

75-46-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name fluoroform

1.2 Other means of identification

Product number -
Other names Fron23

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:75-46-7 SDS

75-46-7Synthetic route

Dimethyl-trifluormethyl-wismut
677-31-6

Dimethyl-trifluormethyl-wismut

trifluoromethan
75-46-7

trifluoromethan

Conditions
ConditionsYield
With sodium hydroxide In water in hot 5n NaOH solution;100%
In water
trifluoromethyldiiodophosphine
421-59-0

trifluoromethyldiiodophosphine

A

sodium phosphite

sodium phosphite

B

trifluoromethan
75-46-7

trifluoromethan

C

sodium iodide
7681-82-5

sodium iodide

Conditions
ConditionsYield
With NaOH In water 20°C (24 h); hydrolysis;A n/a
B 99.5%
C 100%
Methyl-bis-trifluormethyl-wismut
684-13-9

Methyl-bis-trifluormethyl-wismut

trifluoromethan
75-46-7

trifluoromethan

Conditions
ConditionsYield
With sodium hydroxide In water in hot 5n NaOH solution;100%
In water
Diethyl-trifluormethyl-wismut
1998-70-5

Diethyl-trifluormethyl-wismut

trifluoromethan
75-46-7

trifluoromethan

Conditions
ConditionsYield
With sodium hydroxide In water in 5n NaOH solution;100%
In water
Ethyl-bis-trifluormethyl-wismut
1683-91-6

Ethyl-bis-trifluormethyl-wismut

trifluoromethan
75-46-7

trifluoromethan

Conditions
ConditionsYield
With sodium hydroxide In water in hot 5n NaOH;100%
In water
hydroxide

hydroxide

Trifluoro-methanethiosulfonic acid S-trifluoromethyl ester
358-15-6

Trifluoro-methanethiosulfonic acid S-trifluoromethyl ester

A

trifluoromethan
75-46-7

trifluoromethan

B

fluoride

fluoride

C

sulfide ion

sulfide ion

Conditions
ConditionsYield
at 95°C, hydrolysis;A 60%
B 39%
C 99%
Bis(trifluormethyl)-monothiophosphinigsaeure
1486-19-7

Bis(trifluormethyl)-monothiophosphinigsaeure

trifluoromethan
75-46-7

trifluoromethan

Conditions
ConditionsYield
With NaOH In not given hydrolysis at 60-70°C (3 d);99%
Bis(trifluormethyl)-cyanophosphan
431-97-0

Bis(trifluormethyl)-cyanophosphan

sodium hydroxide
1310-73-2

sodium hydroxide

trifluoromethan
75-46-7

trifluoromethan

Conditions
ConditionsYield
In water hydrolysis with 10 % aq. NaOH;;99%
dimethyltrifluoromethylarsenic dichloride
75355-40-7

dimethyltrifluoromethylarsenic dichloride

trifluoromethan
75-46-7

trifluoromethan

Conditions
ConditionsYield
With sodium hydroxide for 4h; Ambient temperature; hydrolysis in sealed tube;98.8%
glycine
56-40-6

glycine

methyl (chloromethyl)(trifluoromethyl)phosphinate
111727-31-2

methyl (chloromethyl)(trifluoromethyl)phosphinate

A

trifluoromethan
75-46-7

trifluoromethan

B

N-(phosphonemethyl)glycine
1071-83-6

N-(phosphonemethyl)glycine

Conditions
ConditionsYield
With sodium hydroxide In ethanol; water at 20℃; Rate constant;A 98%
B 49%
tristrifluoromethylarsine
420-42-8

tristrifluoromethylarsine

trifluoromethan
75-46-7

trifluoromethan

Conditions
ConditionsYield
byproducts: H2; 330°C (40 h); also formation of gray mirror;98%
With NaOH In not given hydrolysis at 105°C (15 h);14.5%
tris(trifluoromethyl)phosphine
432-04-2

tris(trifluoromethyl)phosphine

trifluoromethan
75-46-7

trifluoromethan

Conditions
ConditionsYield
With NaOH In water 48 h, 20°C;98%
With H2O hydrolysis at 200°C, 12 h;46%
ammonolysis at 20°C, 48 h;37%
With H2O In water hydrolysis at 200°C;;
ammonia
7664-41-7

ammonia

A

antimony nitride

antimony nitride

B

trifluoromethan
75-46-7

trifluoromethan

Conditions
ConditionsYield
24 h;A n/a
B 98%
24 h;A n/a
B 98%
1,1,1,2-tetrafluoroethane
811-97-2

1,1,1,2-tetrafluoroethane

A

1,1,1,2,2-pentafluoroethane
354-33-6

1,1,1,2,2-pentafluoroethane

B

Difluoromethane
75-10-5

Difluoromethane

C

trifluoromethan
75-46-7

trifluoromethan

D

Hexafluoroethane
76-16-4

Hexafluoroethane

Conditions
ConditionsYield
With fluorine at 200 - 250℃; Product distribution; Further Variations:; Reagents;A 1.1%
B 0.9%
C 0.4%
D 97.6%
bis(trifluoromethyl)aminoxybis(trifluoromethyl)stibine

bis(trifluoromethyl)aminoxybis(trifluoromethyl)stibine

trifluoromethan
75-46-7

trifluoromethan

Conditions
ConditionsYield
With sodium hydroxide In sodium hydroxide hydrolysis with20 % NaOH soln.;97.3%
With sodium hydroxide with 20 % NaOH;
With NaOH with 20 % NaOH;
(trifluoro methyl) trifluoro germane
1512-15-8

(trifluoro methyl) trifluoro germane

trifluoromethan
75-46-7

trifluoromethan

Conditions
ConditionsYield
With water reaction in hot water;;97%
dichloromethane
75-09-2

dichloromethane

A

methylene chloride
74-87-3

methylene chloride

B

Difluoromethane
75-10-5

Difluoromethane

C

R32
593-70-4

R32

D

trifluoromethan
75-46-7

trifluoromethan

Conditions
ConditionsYield
With hydrogen fluoride; antimony(III) fluoride; antimony pentafluoride at 5 - 100℃; under 12504.7 Torr;A n/a
B 96.9%
C 3.08%
D n/a
antimony pentafluorideA n/a
B 96.4%
C 3.56%
D n/a
methylbistrifluoromethylarsenic dichloride
75368-11-5

methylbistrifluoromethylarsenic dichloride

trifluoromethan
75-46-7

trifluoromethan

Conditions
ConditionsYield
With sodium hydroxide at 125℃; for 20h; hydrolysis in sealed tube;93%
perfluormethylgermanium iodide
1512-08-9

perfluormethylgermanium iodide

trifluoromethan
75-46-7

trifluoromethan

Conditions
ConditionsYield
With water reaction in water in presence of Ag2O;;92%
With water reaction in hot water;;89%
With water reaction in cold water;;2%
S-difluoromethyl-S-mesityl-S-phenylsulfonium tetra(3,5-di(trifluoromethyl)phenyl)borate

S-difluoromethyl-S-mesityl-S-phenylsulfonium tetra(3,5-di(trifluoromethyl)phenyl)borate

trifluoromethan
75-46-7

trifluoromethan

Conditions
ConditionsYield
With tetrabutyl ammonium fluoride In [D3]acetonitrile Reagent/catalyst; Molecular sieve;92%
With tetrabutyl ammonium fluoride In acetonitrile at 20℃; Solvent; Reagent/catalyst; Molecular sieve; Sealed tube;89%
tris(trifluoromethyl)stibane
432-05-3

tris(trifluoromethyl)stibane

dimethyl amine
124-40-3

dimethyl amine

trifluoromethan
75-46-7

trifluoromethan

Conditions
ConditionsYield
20°C (28 d);91%
20°C (28 d);91%
20°C, 28 d;>99
trifluoromethyltrimethylsilane
335-06-8

trifluoromethyltrimethylsilane

A

trifluoromethan
75-46-7

trifluoromethan

B

silicon tetrafluoride
7783-61-1

silicon tetrafluoride

Conditions
ConditionsYield
With sodium hydroxide; water hydrolysis;;A 91%
B n/a
With NaOH; H2O hydrolysis;;A 91%
B n/a
trifluoromethyltrimethylsilane
335-06-8

trifluoromethyltrimethylsilane

A

trifluoromethan
75-46-7

trifluoromethan

B

(trifluoromethyl)silane
10112-11-5

(trifluoromethyl)silane

Conditions
ConditionsYield
With lithium aluminium tetrahydride In dibutyl ether at -78℃; for 0.25h;A n/a
B 90%
tris(trifluoromethyl)stibane
432-05-3

tris(trifluoromethyl)stibane

A

trifluoromethan
75-46-7

trifluoromethan

B

fluoride

fluoride

Conditions
ConditionsYield
With HCl In not given 100°C; concd. HCl;A 90%
B n/a
tetrakis-trifluoromethyl-diarsane
360-56-5

tetrakis-trifluoromethyl-diarsane

trifluoromethan
75-46-7

trifluoromethan

Conditions
ConditionsYield
With NH3 20°C, 28 d in Carius tube;89%
bis(trifluoromethyl)diethylaminophosphane
55865-38-8

bis(trifluoromethyl)diethylaminophosphane

A

trifluoromethan
75-46-7

trifluoromethan

B

bis(trifluoromethyl)phosphinous acid
359-65-9

bis(trifluoromethyl)phosphinous acid

Conditions
ConditionsYield
With toluene-4-sulfonic acid In various solvent(s) at 20℃; for 12h;A n/a
B 88%
bis(trifluoromethyl)phosphine
460-96-8

bis(trifluoromethyl)phosphine

A

Poly(trifluoromethylphosphane)
181234-88-8

Poly(trifluoromethylphosphane)

B

trifluoromethan
75-46-7

trifluoromethan

C

Tetrakis(trifluoromethyl)cyclotetraphosphane
393-02-2

Tetrakis(trifluoromethyl)cyclotetraphosphane

D

pentakis-trifluoromethyl-cyclopentaphosphane
745-23-3, 54548-49-1

pentakis-trifluoromethyl-cyclopentaphosphane

Conditions
ConditionsYield
400°C furnace temp., 5 h;A n/a
B 87%
C n/a
D n/a
400°C furnace temp., 5 h;A n/a
B 87%
C n/a
D n/a
400°C furnace temp., 4 h;A n/a
B 67%
C n/a
D n/a
tris(trifluoromethyl)arsine
432-02-0

tris(trifluoromethyl)arsine

trifluoromethan
75-46-7

trifluoromethan

Conditions
ConditionsYield
With H2O 300°C, 48 h;87%
With NaOH In not given hydrolysis with 0.05 molar NaOH soln.; 20°C, 44 h shaking;87%
In not given hydrolysis with buffer soln.:80% glycine and NaCl mixture, 20% 0.1 molar NaOH (pH=9.2);15%
Caesium-trans-tris(trifluormethyl)-trifluorphosphat
18128-79-5

Caesium-trans-tris(trifluormethyl)-trifluorphosphat

trifluoromethan
75-46-7

trifluoromethan

Conditions
ConditionsYield
With acid In not given87%
(trifluoro methyl) difluoro iodo silane
27668-68-4

(trifluoro methyl) difluoro iodo silane

A

trifluoromethan
75-46-7

trifluoromethan

B

(trifluoromethyl)silane
10112-11-5

(trifluoromethyl)silane

Conditions
ConditionsYield
With lithium aluminium tetrahydride In dibutyl ether at -78℃; for 0.25h;A n/a
B 85%
benzophenone
119-61-9

benzophenone

trifluoromethan
75-46-7

trifluoromethan

1,1-diphenyl-2,2,2-trifluoroethanol
379-18-0

1,1-diphenyl-2,2,2-trifluoroethanol

Conditions
ConditionsYield
With phosphazene base-P4-tert-butyl In tetrahydrofuran; hexane at -40℃; for 3h; Time; Reagent/catalyst; Inert atmosphere;99%
With potassium tert-butylate In N,N-dimethyl-formamide at 20℃; under 750.075 Torr; for 0.000138889h; Solvent; Pressure; Concentration; Flow reactor;98%
With potassium tert-butylate at 20℃; for 6h; Schlenk technique; Cooling with liquid nitrogen;96%
trifluoromethan
75-46-7

trifluoromethan

bis(p-methoxyphenyl)methanone
90-96-0

bis(p-methoxyphenyl)methanone

4,4'-dimethoxy-α-phenyl-α-(trifluoromethyl)benzenemethanol
379-21-5

4,4'-dimethoxy-α-phenyl-α-(trifluoromethyl)benzenemethanol

Conditions
ConditionsYield
Stage #1: trifluoromethan; bis(p-methoxyphenyl)methanone With tris(trimethylsilyl)amine; phosphazene base-P4-tert-butyl In tetrahydrofuran at 20℃; for 14h; Schlenk technique;
Stage #2: With tetrabutyl ammonium fluoride In tetrahydrofuran at 20℃; for 1h; Schlenk technique;
99%
With potassium tert-butylate In N,N-dimethyl-formamide at 20℃; under 750.075 Torr; for 0.000138889h; Flow reactor;74%
trifluoromethan
75-46-7

trifluoromethan

(S)-2-methyl-propane-2-sulfinic acid 1-(4-trifluoromethyl-phenyl)-meth-(E)-ylideneamide
851513-48-9

(S)-2-methyl-propane-2-sulfinic acid 1-(4-trifluoromethyl-phenyl)-meth-(E)-ylideneamide

(S)-2-methyl-N-((R)-2,2,2-trifluoro-1-(4-(trifluoromethyl)phenyl)ethyl)propane-2-sulfinamide

(S)-2-methyl-N-((R)-2,2,2-trifluoro-1-(4-(trifluoromethyl)phenyl)ethyl)propane-2-sulfinamide

Conditions
ConditionsYield
Stage #1: trifluoromethan; (S)-2-methyl-propane-2-sulfinic acid 1-(4-trifluoromethyl-phenyl)-meth-(E)-ylideneamide In toluene at -78℃; for 0.25h; Glovebox; Inert atmosphere;
Stage #2: With phosphazene base-P4-tert-butyl In hexane at -78℃;
99%
trifluoromethan
75-46-7

trifluoromethan

cyclohexanone
108-94-1

cyclohexanone

1-(trifluoromethyl)-1-cyclohexanol
80768-55-4

1-(trifluoromethyl)-1-cyclohexanol

Conditions
ConditionsYield
With potassium hydroxide In dimethyl sulfoxide at 20℃; for 6h; Time; Inert atmosphere;99%
trifluoromethan
75-46-7

trifluoromethan

(2-chlorophenyl)(phenyl)methanone
5162-03-8

(2-chlorophenyl)(phenyl)methanone

2,2,2-trifluoro-1-(2-chlorophenyl)-1-phenylethanol
730-63-2

2,2,2-trifluoro-1-(2-chlorophenyl)-1-phenylethanol

Conditions
ConditionsYield
Stage #1: trifluoromethan; (2-chlorophenyl)(phenyl)methanone With tris(trimethylsilyl)amine; phosphazene base-P4-tert-butyl In tetrahydrofuran at 20℃; for 10h; Schlenk technique;
Stage #2: With tetrabutyl ammonium fluoride In tetrahydrofuran at 20℃; for 1h; Schlenk technique;
98%
With potassium tert-butylate In N,N-dimethyl-formamide at 20℃; under 750.075 Torr; for 0.000138889h; Flow reactor;74%
trifluoromethan
75-46-7

trifluoromethan

deuterofluoroform
558-22-5

deuterofluoroform

Conditions
ConditionsYield
With deuteriated sodium hydroxide; water-d2 at 105℃; for 7h;97.6%
With 4,4'-difluorobiphenyl; cis-[(1,3-bis(diphenylphosphino)propane)Pd(Ph)(OH)]; water-d2 In N,N-dimethyl-formamide at 23℃; for 24h; Inert atmosphere; Glovebox;8%
With water-d2; potassium carbonate at 120℃;
With water at 20℃; Thermodynamic data; Irradiation; H/D separation factors, other temperatures; ΔH;
trifluoromethan
75-46-7

trifluoromethan

(S)-2-methyl-N-(4-methylbenzylidene)propane-2-sulfinamide

(S)-2-methyl-N-(4-methylbenzylidene)propane-2-sulfinamide

(S)-2-methyl-N-((R)-2,2,2-trifluoro-1-(p-tolyl)ethyl)propane-2-sulfinamide

(S)-2-methyl-N-((R)-2,2,2-trifluoro-1-(p-tolyl)ethyl)propane-2-sulfinamide

Conditions
ConditionsYield
With phosphazene base-P4-tert-butyl In hexane; toluene at -78℃; Inert atmosphere; Glovebox; diastereoselective reaction;96%
trifluoromethan
75-46-7

trifluoromethan

acetophenone
98-86-2

acetophenone

1,1,1-trifluoro-2-phenylpropan-2-ol
426-54-0

1,1,1-trifluoro-2-phenylpropan-2-ol

Conditions
ConditionsYield
With phosphazene base-P4-tert-butyl In tetrahydrofuran; hexane at 40℃; for 3h; Inert atmosphere;95%
With tris(trimethylsilyl)amine; tetramethylammonium fluoride In tetrahydrofuran; N,N-dimethyl-formamide at -10 - 20℃; for 6h;26%
With potassium hydroxide In dimethyl sulfoxide at 20℃; for 6h; Time; Inert atmosphere;1%
With tetrabutylammonium (2-pyrrolidonide); 1,1,1,3,3,3-hexamethyl-disilazane 1.) DMF, -10 deg C, 5 h; Yield given. Multistep reaction;
trifluoromethan
75-46-7

trifluoromethan

Diphenylacetonitrile
86-29-3

Diphenylacetonitrile

α-difluoromethyldiphenyl acetonitrile
1427-12-9

α-difluoromethyldiphenyl acetonitrile

Conditions
ConditionsYield
Stage #1: Diphenylacetonitrile With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.0833333h; Inert atmosphere;
Stage #2: trifluoromethan In tetrahydrofuran; hexane at -78℃; for 0.0166667h; Reagent/catalyst; Time; Inert atmosphere;
95%
Stage #1: Diphenylacetonitrile With potassium hydroxide In water for 0.5h;
Stage #2: trifluoromethan In water; acetonitrile at 20℃; for 3h;
30%
trifluoromethan
75-46-7

trifluoromethan

2-(p-Chlorophenyl)-2-phenylacetonitrile
4578-80-7

2-(p-Chlorophenyl)-2-phenylacetonitrile

2-(4-chlorophenyl)-3,3-difluoro-2-phenylpropanenitrile

2-(4-chlorophenyl)-3,3-difluoro-2-phenylpropanenitrile

Conditions
ConditionsYield
Stage #1: 2-(p-Chlorophenyl)-2-phenylacetonitrile With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.0833333h; Inert atmosphere;
Stage #2: trifluoromethan In tetrahydrofuran; hexane at -78℃; Inert atmosphere;
95%
trifluoromethan
75-46-7

trifluoromethan

C12H24KO6(1+)*C13H25B3N3(1-)

C12H24KO6(1+)*C13H25B3N3(1-)

C12H24KO6(1+)*C7H18B3F3N3(1-)

C12H24KO6(1+)*C7H18B3F3N3(1-)

Conditions
ConditionsYield
In tetrahydrofuran at -80℃; under 1484.08 Torr; for 0.166667h; Inert atmosphere;95%
trifluoromethan
75-46-7

trifluoromethan

C21H28N2OS

C21H28N2OS

(R)-N-((2S,3S)-3-(dibenzylamino)-1,1,1-trifluorobutan-2-yl)-2-methylpropane-2-sulfinamide

(R)-N-((2S,3S)-3-(dibenzylamino)-1,1,1-trifluorobutan-2-yl)-2-methylpropane-2-sulfinamide

Conditions
ConditionsYield
With phosphazene base-P4-tert-butyl In toluene at -78℃; for 12h; Schlenk technique; Inert atmosphere; diastereoselective reaction;94%

75-46-7Relevant articles and documents

OXIDATIVE ADDITION OF SUBSTITUTED ARSINES AND STIBINES WITH BIS(TRIFLUOROMETHYL)NITROXYL

Ang, H. G.,Lien, W. S.

, p. 453 - 470 (1980)

Reactions of bis(trifluoromethyl)nitroxyl with a number of methyl- and trifluoromethyl- substituted arsines and stibines at room temperature lead to the formation of pentavalent arsenic and antimony derivatives, namely (CH3)3-n(CF3)nM2 (M = As, n = 0, 1, 2; M = Sb, n = 0, 1).The derivatives yield bis(trifluoromethyl)-hyroxylamine and the corresponding dichlorides on treatment with hydrogen chloride.A free radical mechanism is proposed for the oxidative addition reactions.

-

Coomber, J. W.,Whittle, E.

, p. 2183 - 2190 (1966)

-

Mixed-valence thiophosphorus compounds. Fluoro- and (trifluoromethyl)(thiophosphorylthio)phosphines with chiral phosphorus centers

Cavell, Ronald G.,Doty, Leon F.

, p. 3086 - 3093 (1978)

Reactions of the acids (CF3)2PS2H and F2PS2H with the fluoro(trifluoromethyl)aminophosphine CF3(F)PN(CH3)2 and the reaction of the new acid F(CF3)P(S)SH with the fluoro- or (trifluoromethyl)aminophosphines X2PN(CH3)2 (X = F, CF3) provide new isomeric (thiophosphorylthio)phosphines XYP(S)SPX′Y′ (X, Y, X′, Y′ = F, CF3) with chiral phosphorus centers. The compounds were characterized chemically and by NMR spectroscopy. Geminal CF3-CF3 (9.0 Hz for CF3 on pentavalent P; 7.2 Hz for CF3 on trivalent P) and F-F (82.5 Hz for F on pentavalent P; 92.5 Hz for F on trivalent P) coupling constants are revealed in the NMR spectra of the molecules as a result of the presence of the chiral phosphorus centers. Directly bound geminal fluorine atoms on trivalent P show large chemical shift difference between the two fluorine atoms (4.4 ppm) accompanied by substantially different 1JPF coupling constants (1370 and 1291 Hz). Similar but smaller differences prevail between geminal CF3 substituents. Reaction of the new acid F(CF3)P(S)SH with CF3(F)PN(CH3)2 gave a mixture of (thiophosphorylthio)phosphine isomers each with two chiral phosphorus centers. Only partial assignment of the major features of this spectrum could be made.

REACTIONS OF BIS(TRIFLUOROMETHYL)NITROXYL WITH CF3PX2 (WHERE X=F, Cl, Br, I AND CN) AND P(CN)3

ANG, H. G.,SO, K. K.

, p. 221 - 242 (1982)

The reactions between bis(trifluoromethyl)nitroxyl and CF3PX2 (where X=F, Cl, Br and CN) in 2:1 molar ratio give addition products, 2P(CF3)X2.The bromo and cyano products are unstable.The former decomposes at room temperature to give bromine and perfluoro-2-azapropene, and the latter yields predominantly (CF3)2NOCF3.With CF3PI2, iodine displacement occurs to afford 2PCF3.On the other hand, P(CN)3 affords 3PO, (CF3)2NON(CF3)2 and paracyanogen.Mechanisms for these reactions are proposed.

Non-Arrhenius Behaviour in the Reaction of CF3 Radicals with CH3CN and CD3CN

Pasteris, L.,Staricco, E. H.

, p. 1303 - 1310 (1985)

Evidence is presented that rate measurements over a wide temperature range, 298-648 K, for the reaction of CF3 radicals with methyl cyanide show non-Arrhenius behaviour when the photolysis of trifluoromethyl iodide is used as a source radicals.The results presented here support the fact that the curved Arrhenius plot may be explained in terms of two reaction channels giving the same product, CF3H.One is the abstraction by the CF3 radicals and the other involves the iodine atom produced in the photolysis of CF3I.In order to obtain further information on the reaction mechanism the kinetic isotope effect has also been studied.

Emeleus, H. J.,Haszeldine, R. N.,Paul, R. C.

, (1954)

The gas-phase reaction of the CF3 radical with thiophene

Herrera, Olga S.,Nieto, Jorge D.,Lane, Silvia I.,Oexler, Elena V.

, p. 1477 - 1481 (2003)

The reaction of CF3 radicals, generated by photolysis of CF 3I or hexafluoroacetone with thiophene, was studied in the gas phase at 25°C. At conversion of thiophene less than 20%, monosubstituted CF 3-thiophenes were found as the main reaction products, in addition to CF3H, C2F6, and monosubstituted dihydro-CF3-thiophene, the latter in very low proportion. An isomeric mixture of 2- and 3-CF3-thiophene was obtained in a ratio of about 16, independent of the radical source used (CF3I or hexafluoroacetone) to produce the CF3 radicals. A plausible mechanism that accounts for the observed products is proposed, and the reactivity of thiophene toward the CF3 radical at 25°C was determined as kadd/kc1/2 = 106 ± 4 cm3/2 mol-1/2 s-1/2.

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Fevre, H. F. Le,Timmons, R. B.

, p. 3854 - 3859 (1969)

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Conversion of CFC-13 to trifluoroacetic acid by electrochemical reaction with carbon dioxide

Sonoyama, Noriyuki,Sakata, Tadayoshi

, p. 444 - 445 (2002)

The electrochemical conversion of CFC-13 (CClF3) and carbon dioxide into trifluoroacetic acid (TFAA) was attempted at a Ag wire electrode under high pressure. TFAA was efficiently produced and the current efficiency was slightly dependent on the potential during electrolysis and pressure of co-existing carbon dioxide.

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Ayscough et al.

, p. 743,744 (1955)

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Experimental Measurement of the Electron Affinity of the Hydroperoxy Radical

Bierbaum, Veronica M.,Schmitt, Robert J.,DePuy, Charles H.,Mead, Roy D.,Schulz, P. A.,Lineberger, W. C.

, p. 6262 - 6263 (1981)

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Evaluation of the kinetic parameters for the reaction of trifluoromethyl radicals with CH3Cl in the gas phase in temperature range from 416 to 63 K

Taccone,Olleta,Salinovich

, p. 353 - 362 (1993)

The hydrogen and chlorine atom abstraction reactions from CH3Cl by CF3 radicals produced by the photolysis of hexafluoroacetone (HFA) and CF3I were studied relative to the recombination of CF3 radicals:

Direct C(sp3)?H Trifluoromethylation of Unactivated Alkanes Enabled by Multifunctional Trifluoromethyl Copper Complexes

Choi, Geunho,Lee, Geun Seok,Park, Beomsoon,Kim, Dongwook,Hong, Soon Hyeok

supporting information, p. 5467 - 5474 (2021/01/20)

A mild and operationally simple C(sp3)?H trifluoromethylation method was developed for unactivated alkanes by utilizing a bench-stable CuIII complex, bpyCu(CF3)3, as the initiator of the visible-light photoinduced reaction, the source of a trifluoromethyl radical as a hydrogen atom transfer reagent, and the source of a trifluoromethyl anion for functionalization. The reaction was initiated by the generation of reactive electrophilic carbon-centered CF3 radical through photoinduced homolytic cleavage of bpyCu(CF3)3, followed by hydrogen abstraction from an unactivated C(sp3)?H bond. Comprehensive mechanistic investigations based on a combination of experimental and computational methods suggested that C?CF3 bond formation was enabled by radical–polar crossover and ionic coupling between the resulting carbocation intermediate and the anionic CF3 source. The methylene-selective reaction can be applied to the direct, late-stage trifluoromethylation of natural products and bioactive molecules.

PROCESSES FOR PRODUCING TRIFLUOROIODOMETHANE USING METAL TRIFLUOROACETATES

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Paragraph 0025-0030, (2020/09/19)

The present disclosure provides a process for producing trifluoroiodomethane. The process includes providing a metal trifluoroacetate, iodine, a phase transfer catalyst, and an organic solvent, and reacting the metal trifluoroacetate and iodine in the presence of the phase transfer catalyst and the organic solvent to produce trifluoroiodomethane.

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