192862-14-9

Upstream product

• 106136-95-2 1-(2,4-dichlorophenyl)-2-methylthioethanone 
• 4252-78-2 2,2',4'-trichloroacetophenone 
• 2631-72-3 2,4-dichlorophenacyl bromide 

Downstream Products

• 192862-19-4 2-(2,4-dichlorophenyl)-2-[difluoro(methylthio)methyl]oxirane 
• 192861-88-4 2-(2,4-dichlorophenyl)-1,1-difluoro-1-(methylthio)-3-(1H-1,2,4-triazol-1-yl)-2-propanol 

Relevant academic research and scientific papers

New antifungal 1,2,4-triazoles with difluoro(substituted sulfonyl)methyl moiety

New 1,2,4-triazoles (2) having a difluoro(substituted sulfonyl)methyl moiety were designed and synthesized via α,α-difluoro-α-(substituted thio)acetophenones (3). Compounds (2) showed potent antifungal activities against C. albicans, C. krusei, A. flavus

α, α-gem-difluorination of α-(alkylthio)acetophenone derivatives with N-Fluoropyridinium salts

The α, α-gem-difluorination of 2',4'-difluoro- α(methylthio)acetophenone (1a) with N-fluoropyridinium salts gave 2',4',α-tetrafluoro-α-(methylthio)acetophenone (3a). This reaction was accelerated by the addition of zinc chloride, zinc bromide or anhydrous iron(III) chloride, and higher yields than the reaction without additives were obtained. The gem- difluorination reaction using FP-T300 in the presence of zinc bromide was applicable to other α-(alkylthio)acetophenone derivatives (1).

Triazole derivative and pharmaceutical comprising the same as an effective ingredient

Described is a triazole derivative represented by the formula (1) or salt thereof, preparation process thereof, preparation intermediates represented by the formulas (2) and (3), and a pharmaceutical comprising the compound represented by the formula (1)