192987-92-1

Upstream product

• 170711-05-4 (S)-1-benzyl-3-(benzyloxy)pyrrolidine-2,5-dione 

Downstream Products

• 1011295-42-3 (4S,5R,E)-1-benzyl-4-(benzyloxy)-5-styrylpyrrolidin-2-one 
• 1011295-47-8 (4S,5R)-1-benzyl-4-(benzyloxy)-5-(3,4-dimethoxyphenyl)pyrrolidin-2-one 
• 1011295-46-7 (4S,5R)-1-benzyl-4-(benzyloxy)-5-(4-methoxyphenyl)pyrrolidin-2-one 
• 1011295-44-5 (4S,5S)-5-(benzofuran-2-yl)-1-benzyl-4-(benzyloxy)pyrrolidin-2-one 
• 1011295-45-6 (4S,5R)-1-benzyl-4-(benzyloxy)-5-(2-thienyl)pyrrolidin-2-one 
• 1011295-43-4 (4S,5S)-1-benzyl-4-(benzyloxy)-5-(furan-2-yl)pyrrolidin-2-one 
• 187091-61-8 (-)-(4S,5R)-1-benzyl-4-benzyloxy-5-methyl-2-pyrrolidinone 
• 170711-09-8 (-)-(4S,5R)-1-benzyl-4-benzyloxy-5-sulfonyl-2-pyrrolidinone 

Relevant academic research and scientific papers

An alternative stereoselective synthesis of protected trans-5-alkyl-4- hydroxy-2-pyrrolidinones

A flexible approach to protected trans-5-alkyl-4-hydroxy-2- pyrrolidinones was described. The key step involved the α-amidoalkylation of benzenesulfone derived from (S)-malic acid, with organozinc reagents generated in situ from Grignard reagents and anhydrous ZnCl2·OEt2.