An alternative stereoselective synthesis of protected trans-5-alkyl-4- hydroxy-2-pyrrolidinones

Article abstract of DOI:10.1080/00397910008086864

A flexible approach to protected trans-5-alkyl-4-hydroxy-2- pyrrolidinones was described. The key step involved the α-amidoalkylation of benzenesulfone derived from (S)-malic acid, with organozinc reagents generated in situ from Grignard reagents and anhydrous ZnCl₂·OEt₂.

Full text of DOI:10.1080/00397910008086864

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Synthetic Communications: An
International Journal for Rapid
Communication of Synthetic
Organic Chemistry
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An Alternative Stereoselective
Synthesis of Protected
Trans-5-Alkyl-4-Hydroxy-2-
Pyrrolidinones
Pei Qiang Huang a , Xu Tang a & An Qi Chen a
a Department of Chemistry , Xiamen University ,
Fujian, Xiamen, 361005, PR CHINA
Published online: 04 Dec 2007.
To cite this article: Pei Qiang Huang , Xu Tang & An Qi Chen (2000) An Alternative
Stereoselective Synthesis of Protected Trans-5-Alkyl-4-Hydroxy-2-Pyrrolidinones,
Synthetic Communications: An International Journal for Rapid Communication of
Synthetic Organic Chemistry, 30:13, 2259-2268, DOI: 10.1080/00397910008086864
To link to this article: http://dx.doi.org/10.1080/00397910008086864
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