192993-85-4Relevant academic research and scientific papers
Construction of the tetracyclic core of (±)-cycloclavine and 4-amino Uhle's ketone
Chen, Jin-Quan,Mi, Yang,Shi, Zi-Fa,Cao, Xiao-Ping
, p. 3801 - 3808 (2018)
A rapid construction of the tetracyclic core (±)-2 of (±)-cycloclavine (1) was accomplished in seven steps and 24% overall yield from commercially available aldehyde 7. Key features include a domino Friedel-Crafts/nitro-Michael reaction to construct the C
Thiazolidinedione derivatives, method for preparing the derivatives and pharmaceutical compositions containing same
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, (2008/06/13)
A thiazolidinedione derivative represented by the following general formula (I): STR1 ?wherein the dotted line represents a single bond or a double bond, the thiazolidinedione ring residue is linked to either of 2-, 3-, 4-, 5- and 6-positions on the indole ring and R represents a group selected from the group consisting of hydrogen atom and alkyl, alkenyl, alkynyl, phenyl, aralkyl, heterocycloalkyl, arylsulfonyl and arylaminocarbonyl groups! or a pharmaceutically acceptable salt thereof exhibits excellent effects of reducing the blood sugar level and of reducing the lipid concentration in blood and is accordingly useful as a therapeutic agent for treating diabates mellitus. These derivatives and pharmaceutically acceptable salt thereof are almost free of any side effect.
