193010-40-1

Upstream product

• 556-96-7 5-bromo-1,3-xylene 
• 51760-23-7 1-bromo-3,5-bis(bromomethyl)benzene 
• 179179-29-4 2,2'-(5-bromo-1,3-phenylene)bis(2-methylpropanenitrile) 

Downstream Products

• 1374658-80-6 dimethyl 2,2′-(5-bromo-1,3-phenylene)diacetate 
• 193010-44-5 5-bromo-1,3-bis(3-oxo-2,4,5-triphenylcyclopenta-1,4-dienyl)benzene 
• 193010-42-3 1-[3-Bromo-5-(2-oxo-2-phenyl-acetyl)-phenyl]-2-phenyl-ethane-1,2-dione 

Relevant academic research and scientific papers

Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design

The discovery and optimization of non-nucleoside dengue viral RNA-dependent-RNA polymerase (RdRp) inhibitors are described. An X-ray-based fragment screen of Novartis fragment collection resulted in the identification of a biphenyl acetic acid fragment 3, which bound in the palm subdomain of RdRp. Subsequent optimization of the fragment hit 3, relying on structure-based design, resulted in a >1000-fold improvement in potency in vitro and acquired antidengue activity against all four serotypes with low micromolar EC50 in cell-based assays. The lead candidate 27 interacts with a novel binding pocket in the palm subdomain of the RdRp and exerts a promising activity against all clinically relevant dengue serotypes.

The albatrossenes: Large, cleft-containing, polyphenyl polycyclic aromatic hydrocarbons

The syntheses and X-ray structures of very large polycyclic aromatic compounds containing clefts defined by polyphenylaryl groups are described. The C2-symmetric 'albatrossenes' 1,3-bis(heptaphenyl-2-naphthyl)benzene (7a) and 1,3-bis(heptaphenyl-1-naphthyl)benzene (12a), as well as brominated derivatives, were synthesized by the addition of tetraphenylbenzyne to the appropriate polyphenyl biscyclopentadienones. The 2-naphthyl isomers have wide, shallow clefts, and the 1-naphthyl isomers have deep, narrow clefts which were observed to change size dramatically in different crystal environments. In a similar way, 1,3,5-tris(pentaphenylphenyl)benzene (19), a D3-symmetric molecular propeller with a diameter of 21 ?, and 1,3,5-tris(heptaphenyl-2-naphthyl)benzene (22) were prepared by the addition of diphenylacetylene and tetraphenylbenzyne, respectively, to a triscyclopentadienone.