193023-50-6Relevant academic research and scientific papers
A Sequential Umpolung/Enzymatic Dynamic Kinetic Resolution Strategy for the Synthesis of γ-Lactones
Maskeri, Mark A.,Schrader, Malte L.,Scheidt, Karl A.
, p. 5794 - 5798 (2020)
Combining biological and small-molecule catalysts under a chemoenzymatic manifold presents a series of significant advantages to the synthetic community. We report herein the successful development of a two-step/single flask synthesis of γ-lactones through the merger of Umpolung catalysis with a ketoreductase-catalyzed dynamic kinetic resolution, reduction, and cyclization. This combined approach delivers highly enantio- and diastereoenriched heterocycles and demonstrates the feasibility of integrating NHC catalysis with enzymatic processes.
Opening of cyclopropyl ketones with SmI2 . Synthesis of spirocyclic and bicyclic ketones by intramolecular trapping of an electrophile
Molander, Gary A.,Alonso-Alija, Cristina
, p. 8067 - 8084 (2007/10/03)
A method for the opening of cyclopropyl ketones with samarium (II) iodide followed by the intramolecular trapping of an electrophile is described. This process leads to the obtainment of functionalized spirocyclic, bicyclic, and tricyclic ketones in moderate to good yields.
