19303-08-3Relevant articles and documents
HETEROCYCLIC COMPOUNDS AS EP4 RECEPTOR ANTAGONISTS
-
Paragraph 0289; 0290; 0295, (2016/05/09)
The present invention provides a compound represented by the formula (1): wherein each symbol is as defined in the specification or a salt thereof has an EP4 receptor antagonistic action, and is useful as an agent for the prophylaxis or treatment of EP4 receptor associated diseases (e.g., rheumatoid arthritis, aortic aneurysm, endometriosis, ankylosing spondylitis, inflammatory breast cancer etc.) and the like.
POLYMERIC Pd CATALYSTS FOR THE REDUCTION OF ACETAMIDOCINNAMIC ACID AZLACTONE AND ITS SOLVOLYSIS PRODUCTS
Karpeiskaya, I. E.,Godunova, L. F.,Levitina, E. S.,Lyubeznova, M. R.,Klabunovskii, E. I.,et al.
, p. 1858 - 1867 (2007/10/02)
Pd complexes have been obtained from linear and cross-linked copolymers of R,S-, R-, and S-1-(4-vinylphenyl)ethylamine (1) with styrene and divinylbenzene.Reduction of these compounds gave catalysts which were active in the reductive solvolysis of α-acetaminocinnamic acid azlactone (2) and hydrogenation of the solvolysis products α-acetamidocinnamic acid (ACA), its esters, and its 1-phenylethylamide.The catalysts showed no enantioselective properties in the reductive hydrolysis, but were more active than the catalyst obtained in the absence of the polymer (the "monomeric" analog).The use of polymeric catalysts has shown that, in reductive aminolysis, the chiral nucleophile plays the dominant part in determining the stereoselectivity of the reaction, rather than the chiral ligand of the catalytic complex.The polymer matrix stabilizes the low-valent state of the palladium in the complex.In the hydrogenation of ACA and its esters, the catalyst on the cross-linked polymer is much more active than its "monomeric" analog, but showed no enantioselectivity.Hydrogenation of acetamidocinnamic acid R- and S-1-phenylethylamides on a chiral Pd-polymer catalyst occurred with double asymmetric induction.Keywords: Pd catalysts on chiral polymers, asymmetric reduction, azlactones, reductive aminolysis.
Optically active styrene derivatives, polymers obtained from these, complexes with iridium(I) and their use
-
, (2008/06/13)
Optically active compounds of the formula I STR1 in which R1 is C1 -C4 -alkyl, phenyl or benzyl, R2 is a radical of the formula II or IIa STR2 in which R3 is H or --CH3, or R1 and R2 together form a radical of the formula STR3 in which R2 has the meaning given above; and * represents predominantly R or predominantly S configuration. The compounds can be polymerized to give homopolymers or copolymers. The compounds and the polymers can be complexed with iridium(I) salts in the presence of a diene. The complexes are suitable as enantioselective catalysts.
