193070-18-7Relevant academic research and scientific papers
HETEROCYCLYC SULFONAMIDES HAVING EDG-I ANTAGONISTIC ACTIVITY
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Page/Page column 181, (2008/12/05)
The invention relates to chemical compounds of formula (I), (Ia) and (Ib) or pharmaceutically acceptable salts thereof, which possess Edg-1 antagonistic activity and are accordingly useful for their anti-cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments for use in the production of an anti-cancer effect in a warm-blooded animal, such as man.
Benzimidazole and pyridylimidazole derivatives
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, (2008/06/13)
This invention relates to benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds, all of which may be described by of Formula I The invention is particularly related to such compounds that bind with high selectivity and high affinity to the benzodiazepine site of GABAA receptors. This invention also relates to pharmaceutical compositions comprising such compounds and to the use of such compounds in treatment of certain central nervous system (CNS) diseases. Novel processes for preparing compounds of Formula I are disclosed. This invention also relates to the use of benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds of Formula I in combination with one or more other CNS agents to potentiate the effects of the other CNS agents. Additionally this invention relates to the use such compounds as probes for the localization of GABAA receptors in tissue sections.
Electron deficient flavin as catalyst for baeyer-villiger reaction: Oxidation of cyclobutanones to γ-lactones using hydrogen peroxide
Mazzini, Claudio
, p. 1161 - 1167 (2007/10/03)
The use of an electron deficient isoalloxazine derivative as coenzyme model for the Baeyer-Villiger oxidation is described. This allows, in the presence of hydrogen peroxide, the catalytic oxidation of cyclobutanones into the corresponding γ-lactones with good to excellent yields.
