193071-52-2

Upstream product

• 250280-60-5 (4S)-4-Benzyl-5,5-dimethyl-3-[(2S)-2-methyl-6-heptenoyl]-1,3-oxazolidin-2-one 

Downstream Products

• 152044-53-6 epithilone A 
• 342607-31-2 benzoic acid (1R)-[(4S)-methyl-5-(triisopropyl-silanyloxy)-pentyl]-prop-2-ynyl ester 
• 214892-53-2 (3S,10S)-10-[(1S)-(p-methoxybenzyloxy)ethyl]-3-methyl-3,4,5,6,9,10-hexahydrooxecin-2-one 
• 214892-55-4 (2S,3S,2'S)-2-(p-methoxybenzyloxy)-3-(2'-methylhept-6'-enoyl)-hex-5-ene 
• 186692-73-9 desoxyepothilone A 
• 209260-19-5 (E)-(6R,7S,8S)-7-Hydroxy-4,4,6,8-tetramethyl-5-oxo-trideca-2,12-dienoic acid (S)-1-(tert-butyl-diphenyl-silanyloxymethyl)-but-3-enyl ester 
• 209260-20-8 (E)-(6S,7R,8S)-7-Hydroxy-4,4,6,8-tetramethyl-5-oxo-trideca-2,12-dienoic acid (S)-1-(tert-butyl-diphenyl-silanyloxymethyl)-but-3-enyl ester 
• 209260-24-2 (E)-(6R,7S,8S)-7-Hydroxy-4,4,6,8-tetramethyl-5-oxo-trideca-2,12-dienoic acid (R)-1-(tert-butyl-diphenyl-silanyloxymethyl)-but-3-enyl ester 
• 209260-25-3 (E)-(6S,7R,8S)-7-Hydroxy-4,4,6,8-tetramethyl-5-oxo-trideca-2,12-dienoic acid (R)-1-(tert-butyl-diphenyl-silanyloxymethyl)-but-3-enyl ester 
• 209260-21-9 (3E,13E)-(7R,8S,9S,16S)-16-(tert-Butyl-diphenyl-silanyloxymethyl)-8-hydroxy-5,5,7,9-tetramethyl-oxacyclohexadeca-3,13-diene-2,6-dione 
• 209260-22-0 (3E,13E)-(7S,8R,9S,16S)-16-(tert-Butyl-diphenyl-silanyloxymethyl)-8-hydroxy-5,5,7,9-tetramethyl-oxacyclohexadeca-3,13-diene-2,6-dione 

Relevant academic research and scientific papers

Total synthesis of (-)-epothilone A

The total synthesis of (-)-epothilone A by a convergent route is reported. The synthesis of the required key intermediates has been improved with respect to stereoselectivity and availability. The access to ethyl ketone 2 has been significantly improved b