193086-69-0Relevant academic research and scientific papers
A simple preparation of N-protected chiral α-aminonitriles from N-protected α-amino acid amides
Maetz, Philippe,Rodriguez, Marc
, p. 4221 - 4222 (1997)
N-protected α-amino-acid amides are dehydrated to N-protected α-aminonitriles in good yields and with excellent purities by reaction of the corresponding primary amides with cyanuric chloride in DMF.
Dehydration of Chiral α-Amides to Chiral α-Nitriles Under the Appel Reaction Conditions
Shekharappa,Roopesh Kumar,Srinivasulu,Sureshbabu, Vommina V.
, p. 497 - 502 (2020/07/30)
An efficient synthesis of Nα-protected amino nitriles from Nα-protected amino acid amides employing Ph3P, I2 and NMM was described. Various amino acid amides, protected by Fmoc, Z and Boc were conveniently conve
One-pot synthesis of orthogonally protected dipeptide selenazoles employing Nα-amino selenocarboxamides and α-bromomethyl ketones
Madhu, Chilakapati,Panguluri, Nageswara Rao,Narendra,Panduranga,Sureshbabu, Vommina V.
, p. 6831 - 6835 (2015/01/09)
A simple and efficient protocol for the synthesis of selenazole containing dipeptidomimetics using Nα-amino selenocarboxamides and α-bromomethyl ketones is described. All the compounds made were isolated in good yields and fully characterized.
A novel approach to the solid-phase synthesis of peptides with a tetrazole at the C-terminus
Gunn, Sarah J.,Baker, Alison,Bertram, Richard D.,Warriner, Stuart L.
, p. 2643 - 2646 (2008/02/12)
Peptidomimetics containing a C-terminal tetrazole can be easily prepared using modifications to traditional peptide synthesis protocols. Georg Thieme Verlag Stuttgart.
Syntheses of Fmoc-α-aminoalkyltetrazoles and tetrazole analogue of Leu-enkephalin
Manturewicz,Kosson,Grzonka
, p. 1327 - 1334 (2008/09/18)
Five Fmoc-α-aminoalkyltetrazoles were synthesized starting from Fmoc-α-amino acids. Fmoc-LeuT was applied in synthesis of tetrazole analogue of Leu-enkephalin by solid phase peptide synthesis (SPPS), as well as in solution. Radioreceptor assays showed hig
Synthesis of tetrazole analogues of amino acids using Fmoc chemistry: isolation of amino free tetrazoles and their incorporation into peptides
Sureshbabu, Vommina V.,Venkataramanarao, Rao,Naik, Shankar A.,Chennakrishnareddy
, p. 7038 - 7041 (2008/03/12)
An efficient synthesis of tetrazole analogues of amino acids starting from Nα-Fmoc amino acid in a three-step protocol is reported. The free amino tetrazoles were obtained in good yields and with excellent purity after removal of the Fmoc group
