A simple preparation of N-protected chiral α-aminonitriles from N-protected α-amino acid amides

Article abstract of DOI:10.1016/S0040-4039(97)00895-2

N-protected α-amino-acid amides are dehydrated to N-protected α-aminonitriles in good yields and with excellent purities by reaction of the corresponding primary amides with cyanuric chloride in DMF.