193152-98-6Relevant academic research and scientific papers
Optimization of the beta-aminoester class of factor Xa inhibitors. Part 2: Identification of FXV673 as a potent and selective inhibitor with excellent In vivo anticoagulant activity.
Guertin, Kevin R,Gardner, Charles J,Klein, Scott I,Zulli, Allison L,Czekaj, Mark,Gong, Yong,Spada, Alfred P,Cheney, Daniel L,Maignan, Sebastian,Guilloteau, Jean-Pierre,Brown, Karen D,Colussi, Dennis J,Chu, Valeria,Heran, Christopher L,Morgan, Suzanne R,Bentley, Ross G,Dunwiddie, Christopher T,Leadley, Robert J,Pauls, Henry W
, p. 1671 - 1674 (2002)
Further optimization of the beta-aminoester class of factor Xa (fXa) inhibitors is described culminating in the identification of 9c (FXV673), a potent and selective factor Xa inhibitor with excellent in vivo anticoagulant activity. An X-ray structure of FXV673 bound to human fXa is also presented. Based on its selectivity, potent in vivo activity and favorable pre-clinical safety profile, FXV673 was selected for further development and is currently undergoing clinical trials.
