4385-75-5

Basic information

• Product Name: 4-PYRIDIN-3-YL-BENZOIC ACID
• Synonyms: AKOS BAR-0406;4-(3-PYRIDINYL)BENZOIC ACID;4-(3'-PYRIDYL)BENZOIC ACID;4-(3-PYRIDYL)BENZOIC ACID;4-PYRIDIN-3-YL-BENZOIC ACID;4-PYRID-3-YLBENZOIC ACID;4-Pyridin-3-yl-benzoicacid95%;4-Pyridin-3-ylbenzoic acid 97%
• CAS NO: 4385-75-5
• Molecular Formula: C₁₂H₉NO₂
• Molecular Weight: 199.21
• EINECS: 256-495-9
• Product Categories: pharmacetical;API intermediates;Building Blocks;Carboxy;Pyridine
• Mol File: 4385-75-5.mol
• Article Data: 16

Chemical Properties

• Melting Point: 271-274
• Boiling Point: 398.8 °C at 760 mmHg
• Flash Point: 195 °C
• Appearance: /
• Density: 1.241 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.65±0.10(Predicted)
• CAS DataBase Reference: 4-PYRIDIN-3-YL-BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-PYRIDIN-3-YL-BENZOIC ACID(4385-75-5)
• EPA Substance Registry System: 4-PYRIDIN-3-YL-BENZOIC ACID(4385-75-5)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 4385-75-5(Hazardous Substances Data)

Usage

General Description

4-Pyridin-3-yl-benzoic acid is a chemical compound with a molecular formula C12H9NO2. It is a member of the benzoic acid family and contains a pyridine ring attached to a benzoic acid group. 4-PYRIDIN-3-YL-BENZOIC ACID is often used as a building block in the synthesis of pharmaceuticals and agrochemicals due to its diverse reactivity and potential biological activity. It may also have applications in organic synthesis and material science due to its unique structure and properties. 4-Pyridin-3-yl-benzoic acid is an important intermediate in the production of various compounds and has potential utility in a wide range of industries.

Upstream product

• 14047-29-1 4-carboxyphenylboronic acid 
• 65520-08-3 3-bromopyridine hydrochloride 
• 586-76-5 4-Bromobenzoic acid 
• 619-42-1 4-methoxycarbonylphenyl bromide 
• 1692-25-7 3-pyridylboronic acid 
• 127406-55-7 4-(pyridin-3-yl)benzaldehyde 
• 626-55-1 3-Bromopyridine 
• 25487-66-5 3-Carboxyphenylboronic acid 
• 5720-05-8 4-methylphenylboronic acid 
• 106-38-7 para-bromotoluene 
• 90395-47-4 methyl 4-(3-pyridinyl)benzoate 
• 4385-71-1 4-(pyridin-3-yl)benzoic acid ethyl ester 
• 87199-17-5 4-formylphenylboronic acid, 

Downstream Products

• 129013-83-8 3-(4-bromophenyl)pyridine 
• 78313-73-2 3-(p-iodophenyl)pyridine 
• 1008-88-4 3-phenylpyridine 
• 929203-04-3 3-[4-(4,4,5,5,-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]pyridine 

Relevant articles and documents

Design, synthesis and stepwise optimization of nitrile-based inhibitors of cathepsins B and L

Human cathepsin B (CatB) is an important biological target in cancer therapy. In this work, we performed a knowledge-based design approach and the synthesis of a new set of 19 peptide-like nitrile-based cathepsin inhibitors. Reported compounds were assayed against a panel of human cysteine proteases: CatB, CatL, CatK, and CatS. Three compounds (7h, 7i, and 7j) displayed nanomolar inhibition of CatB and selectivity over CatK and CatL. The selectivity was achieved by using the combination of a para biphenyl ring at P3, halogenated phenylalanine in P2 and Thr-O-Bz group at P1. Likewise, compounds 7i and 7j showed selective CatB inhibition among the panel of enzymes studied. We have also described a successful example of bioisosteric replacement of the amide bond for a sulfonamide one [7e → 6b], where we observed an increase in affinity and selectivity for CatB while lowering the compound lipophilicity (ilogP). Our knowledge-based design approach and the respective structure–activity relationships provide insights into the specific ligand-target interactions for therapeutically relevant cathepsins.

Cadmium-based metal organic framework material as well as preparation method and application thereof

The invention discloses a cadmium-based metal organic framework material as well as a preparation method and an application thereof. The preparation method of the cadmium-based metal organic frameworkmaterial comprises steps as follows: 1) synthesis of li

PYRROLIDINE OR THIAZOLIDINE CARBOXYLIC ACID DERIVATIVES, PHARMACEUTICAL COMPOSITION AND METHODS FOR USE IN TREATING METABOLIC DISORDERSAS AS AGONISTS OF G- PROTEIN COUPLED RECEPTOR 43 (GPR43)

The present invention is directed to novel compounds of formula (I) and their use in treating and/or preventing metabolic diseases.