193205-16-2Relevant academic research and scientific papers
Identification of a potent and selective ρ1 receptor agonist potentiating NGF-induced neurite outgrowth in PC12 cells
Rossi, Daniela,Pedrali, Alice,Urbano, Mariangela,Gaggeri, Raffaella,Serra, Massimo,Fernández, Leyden,Fernández, Michael,Caballero, Julio,Ronsisvalle, Simone,Prezzavento, Orazio,Schepmann, Dirk,Wuensch, Bernhard,Peviani, Marco,Curti, Daniela,Azzolina, Ornella,Collina, Simona
, p. 6210 - 6224 (2011)
Herein we report the synthesis, drug-likeness evaluation, and in vitro studies of new sigma (ρ) ligands based on arylalkenylaminic scaffold. For the most active olefin the corresponding arylalkylamine was studied. Novel arylalkenylamines generally possess
Gaining in pan-affinity towards sigma 1 and sigma 2 receptors. SAR studies on arylalkylamines
Rossi, Daniela,Rui, Marta,Di Giacomo, Marcello,Schepmann, Dirk,Wünsch, Bernhard,Monteleone, Stefania,Liedl, Klaus R.,Collina, Simona
, p. 11 - 19 (2016/12/22)
Sigma Receptor (SR) modulators are involved in different signal transduction pathways, representing important pharmacological/therapeutic tools in several pathological conditions, such as neurodegenerative diseases and cancers. To this purpose, numerous c
Novel enantiopure sigma receptor modulators: Quick (semi-)preparative chiral resolution via hplc and absolute configuration assignment
Rui, Marta,Marra, Annamaria,Pace, Vittorio,Juza, Markus,Rossi, Daniela,Collina, Simona
, (2016/09/23)
The identification of novel pan-sigma receptor (SR) modulators, potentially useful in cancer treatment, represents a new goal of our research. Here, we report on the preparation of novel chiral compounds characterized by a 3-C alkyl chain bridging an arom
