193206-35-8

Basic information

• Product Name: 4-Dimethylamino-N-(4-nitro-phenyl)-butyramide
• CAS NO: 193206-35-8
• Molecular Weight: 251.285
• Mol File: 193206-35-8.mol

Chemical Properties

• CAS DataBase Reference: 4-Dimethylamino-N-(4-nitro-phenyl)-butyramide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Dimethylamino-N-(4-nitro-phenyl)-butyramide(193206-35-8)
• EPA Substance Registry System: 4-Dimethylamino-N-(4-nitro-phenyl)-butyramide(193206-35-8)

Safety Data

• Hazardous Substances Data: 193206-35-8(Hazardous Substances Data)

Upstream product

• 100-01-6 4-nitro-aniline 
• 693-11-8 4-dimethylamino-butyric acid 
• 69954-66-1 4-(dimethylamino)butyric acid hydrochloride 

Downstream Products

• 193206-37-0 N-[4-(4-Dimethylamino-butyrylamino)-phenyl]-isophthalamic acid 
• 193206-36-9 N-(4-Amino-phenyl)-4-dimethylamino-butyramide 

Relevant articles and documents

The discovery of highly potent thp derivatives as octn2 inhibitors: From structure‐based virtual screening to in vivo biological activity

A mismatch between β‐oxidation and the tricarboxylic acid cycle (TCA) cycle flux in mitochondria produces an accumulation of lipid metabolic intermediates, resulting in both blunted metabolic flexibility and decreased glucose utilization in the affected cells. The ability of the cell to switch to glucose as an energy substrate can be restored by reducing the reliance of the cell on fatty acid oxidation. The inhibition of the carnitine system, limiting the carnitine shuttle to the oxidation of lipids in the mitochondria, allows cells to develop a high plasticity to metabolic rewiring with a decrease in fatty acid oxidation and a parallel increase in glucose oxidation. We found that 3‐(2,2,2‐ trimethylhydrazine)propionate (THP), which is able to reduce cellular carnitine levels by blocking both carnitine biosynthesis and the cell membrane carnitine/organic cation transporter (OCTN2), was reported to improve mitochondrial dysfunction in several diseases, such as Huntington’s disease (HD). Here, new THP‐derived carnitine‐lowering agents (TCL), characterized by a high affinity for the OCTN2 with a minimal effect on carnitine synthesis, were developed, and their biological activities were evaluated in both in vitro and in vivo HD models. Certain compounds showed promising biological activities: reducing protein aggregates in HD cells, ameliorating motility defects, and increasing the lifespan of HD Drosophila melanogaster.

Two-ring DNA minor-groove binders consisting of readily available, di-substituted benzene derivatives

DNA minor-groove binders consisting of two disubstituted benzene rings were prepared. Two ligands showed sequence selectivities higher than some of the best known minor-groove binders containing six-membered rings. Reversing the orientation of amide linkages in one ligand leads to another one with relaxed binding to AT sequences and greatly increased affinity toward GC sequences.