193206-40-5

Upstream product

• 693-11-8 4-dimethylamino-butyric acid 
• 99-09-2 3-nitro-aniline 
• 67852-95-3 4-benzyloxycarbonyl-benzoyl chloride 
• 193206-38-1 4-Dimethylamino-N-(3-nitro-phenyl)-butyramide 
• 193206-39-2 N-(3-Amino-phenyl)-4-dimethylamino-butyramide 
• 18520-63-3 monobenzyl terephthalate 

Relevant academic research and scientific papers

Synthesis and biological activity of benzamide DNA minor groove binders

A range of di- and triaryl benzamides were synthesised to investigate the effect of the presence and nature of a polar sidechain, bonding and substitution patterns and functionalisation of benzylic substituents. These compounds were tested for their antiproliferative activity as well as their DNA binding activity. The most active compounds in all assays were unsymmetrical triaryl benzamides with a bulky or alkylating benzylic substituent and a polar amino sidechain.

Two-ring DNA minor-groove binders consisting of readily available, di-substituted benzene derivatives

DNA minor-groove binders consisting of two disubstituted benzene rings were prepared. Two ligands showed sequence selectivities higher than some of the best known minor-groove binders containing six-membered rings. Reversing the orientation of amide linkages in one ligand leads to another one with relaxed binding to AT sequences and greatly increased affinity toward GC sequences.