193356-99-9Relevant academic research and scientific papers
Pyrimidine-2,4-diamines as antiplasmodial antifolates
Seanego, Tswene D.,Klein, Hanna F.,Jansen van Vuuren, Natasha C.,Van Zyl, Robyn L.,Rousseau, Amanda L.
, p. 344 - 361 (2020)
Two series of substituted pyrimidine-2,4-diamines with a flexible side chain at either the 5- or 6-position of the pyrimdine ring were designed as potential inhibitors of P. falciparum dihydrofolate reductase (DHFR). The compounds were synthesised and eva
