193357-58-3Relevant academic research and scientific papers
Synthesis of tetralin and chromane derivatives via In-catalyzed intramolecular hydroarylation
Xie, Kai,Wang, Sizhuo,Li, Ping,Li, Xiujian,Yang, Zhiyong,An, Xiangyu,Guo, Can-Cheng,Tan, Ze
, p. 4466 - 4469 (2010)
In(OTf)3 was found to be an effective catalyst for the cyclization of ω-aryl-1-alkenes to form tetralin and chromane derivatives. Compared with the known Ru-catalyzed version, the In-catalyzed intramolecular cyclization was found to give higher yields and cleaner reactions in some cases. The use of cheaper indium salts instead of the expensive noble metal Ru can be advantageous when the reaction is run on a large scale.
4-substituted piperidine analogs and their use as subtype selective NMDA receptor antagonists
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, (2011/05/18)
PCT No. PCT/US96/20872 Sec. 371 Date Sep. 16, 1998 Sec. 102(e) Date Sep. 16, 1998 PCT Filed Dec. 20, 1996 PCT Pub. No. WO97/23216 PCT Pub. Date Jul. 3, 1997Novel 4-substituted piperidine analogs, pharmaceutical compositions containing the same and the method of using 4-substituted piperidine analogs are selective active antagonists of N-methyl-D-aspartate (NMDA) receptor subtypes for treating conditions such as stroke, cerebral ischemia, central nervous system trauma, hypoglycemia, psychosis, anxiety, migraine headaches, glaucoma, CMV retinitis, aminoglycoside antibiotics-induced hearing loss, convulsions, chronic pain, opioid tolerance or withdrawal, urinary incontinence or neurodegenerative disorders, such as lathyrism, Alzheimer's Disease, Parkinsonism and Huntington's Disease are described.
