193481-99-1Relevant academic research and scientific papers
Discovery of 1-{4-[3-Fluoro-4-((3 S,6 R)-3-methyl-1,1-dioxo-6-phenyl-[1,2]thiazinan-2-ylmethyl)-phenyl]-piperazin-1-yl}-ethanone (GNE-3500): A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C (RORc or RORγ) Inver
Fauber, Benjamin P.,René, Olivier,Deng, Yuzhong,Devoss, Jason,Eidenschenk, Céline,Everett, Christine,Ganguli, Arunima,Gobbi, Alberto,Hawkins, Julie,Johnson, Adam R.,La, Hank,Lesch, Justin,Lockey, Peter,Norman, Maxine,Ouyang, Wenjun,Summerhill, Susan,Wong, Harvey
, p. 5308 - 5322 (2015/08/03)
Retinoic acid receptor-related orphan receptor C (RORc, RORγ, or NR1F3) is a nuclear receptor that plays a major role in the production of interleukin (IL)-17. Considerable efforts have been directed toward the discovery of selective RORc inverse agonists
From α,α-disubstituted α-aminonitriles to heterocycles: Synthesis of derivatives of 4-amino-29-dihydroisothiazole 1,1-dioxide, a new heterocyclic ring system
Marco, Jose L.,Ingate, Simon
, p. 4835 - 4836 (2007/10/03)
The synthesis of derivatives of 4-amino-2,3-dihydroisothiazole 1,1-dioxide (8-10, 12, 15, 16), a new heterocyclic ring system; from α,α-disubstituted α-aminonitriles, is described.
Studies into the synthesis of derivatives of 4-amino-2,3-dihydroisothiazole 1,1-dioxides and 4-amino-1,2-oxathiole 2,2-dioxides, the search for linked π-system containing analogues as potential inhibitors of HIV-1 reverse transcriptase
Ingate, Simon T.,Marco, Jose L.,Witvrouw, Myriam,Pannecouque, Cristophe,De Clercq, Erik
, p. 17795 - 17814 (2007/10/03)
The synthesis, and anti HIV-1 activity, of new derivatives of 4-amino-1,2-oxathiole 2,2-dioxide (3, 5, 6 and 9) and 4-amino-2,3-dihydroisothiazole 1,1-dioxide (14), a new heterocyclic ring system, is described.
