19355-69-2

Basic information

• Product Name: 2-AMINO-2-METHYL-PROPIONITRILE
• Synonyms: 2-cyanoisopropylamine;alpha-aminoisobutyronitrile;aminodimethylacetonitrile;2-amino-2-methylpropiononitrile;N-CYANO-N'-METHYL ETHYLAMIDINE;2-Aminoisobutyricacidnitrile;EINECS 242-989-3;2，2-dimethyl-2-amino acetonitrial，2-amino 2-methyl propanenitrile
• CAS NO: 19355-69-2
• Molecular Formula: C₄H₈N₂
• Molecular Weight: 84.12
• EINECS: 242-989-3
• Product Categories: Small molecule;Aliphatics;Amines
• Mol File: 19355-69-2.mol
• Article Data: 37

Chemical Properties

• Boiling Point: 150.4 °C at 760 mmHg
• Flash Point: 44.7 °C
• Appearance: /
• Density: 0.917 g/cm³
• Vapor Pressure: 0.662mmHg at 25°C
• Refractive Index: 1.434
• Storage Temp.: -20°C Freezer, Under Inert Atmosphere
• PKA: 5.06±0.25(Predicted)
• CAS DataBase Reference: 2-AMINO-2-METHYL-PROPIONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-2-METHYL-PROPIONITRILE(19355-69-2)
• EPA Substance Registry System: 2-AMINO-2-METHYL-PROPIONITRILE(19355-69-2)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 20/21/22-36/37/38-43-41-37/38-22
• Safety Statements: 26-36/37/39-39-36/37
• RIDADR: 3276
• HazardClass: IRRITANT
• Hazardous Substances Data: 19355-69-2(Hazardous Substances Data)

Usage

Chemical Properties

Colourless Oil

InChI:InChI=1/C4H8N2/c1-4(6)2-3-5/h4H,2,6H2,1H3

Upstream product

• 75-86-5 2-hydroxy-2-methylpropanenitrile 
• 773837-37-9 sodium cyanide 
• 67-64-1 acetone 
• 67-56-1 methanol 
• 594-61-6 2-methyllactic acid 
• 7664-41-7 ammonia 
• 126-98-7 methacrylonitrile 
• 75-15-0 carbon disulfide 
• 2273-39-4 2-methylamino-2-methylpropanenitrile 
• 74-89-5 methylamine 
• 143-33-9 sodium cyanide 
• 151-50-8 potassium cyanide 
• 71680-52-9 ammonium cyanide 
• 74-90-8 hydrogen cyanide 

Downstream Products

• 84213-57-0 N-(1-cyano-1-methylethyl)-2-methylpropanamide 
• 118728-63-5 α-isobutyrylamino-isobutyric acid 
• 22977-82-8 4-Amino-3,5-dichloro-N-(cyano-dimethyl-methyl)-benzamide 
• 126517-21-3 N-(2-Benzoyl-4-chlorophenyl)-2-(2-cyano-2-propylamino)acetamide 
• 113308-03-5 N-(Cyano-dimethyl-methyl)-4-(4-ethoxy-phenyl)-2,4-dioxo-butyramide 
• 70842-08-9 5-Imino-4,4-dimethyl-1-(α,α,α,4-tetrafluor-m-tolyl)-2-imidazolidinon 
• 70842-07-8 1-(3-Trifluormethyl-4-chlor-phenyl)-5-imino-4,4-dimethyl-2-imidazolidinon 
• 113308-01-3 N-(Cyano-dimethyl-methyl)-2,4-dioxo-4-phenyl-butyramide 
• 113308-02-4 N-(Cyano-dimethyl-methyl)-2,4-dioxo-4-p-tolyl-butyramide 
• 113308-04-6 4-(4-Bromo-phenyl)-N-(cyano-dimethyl-methyl)-2,4-dioxo-butyramide 
• 17704-74-4 2-Amino-2-methyl-propionamide hydrochloride 
• 16252-90-7 2-amino-2-methylpropanamide 
• 13027-88-8 2-hydroxyisobutyramide 
• 62-57-7 2-Aminoisobutyric acid 

Relevant articles and documents

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Preparation method of enzalutamide intermediate

The invention discloses a preparation method of an enzalutamide intermediate and belongs to the field of pharmaceutical and chemical industry. According to the preparation method of the enzalutamide intermediate, the reaction of every process is high up to higher than 80%, certain reaches up to 93%. Meanwhile, the preparation method of the enzalutamide intermediate is simple in aftertreatment process, easy to operate and applicable to industrializing, mild in reaction conditions and free from severe reaction conditions of high temperature, high pressure and ultralow temperature.

METHOD FOR PRODUCING ALPHA-HYDROXY CARBOXYLIC ESTERS IN THE GAS PHASE

The present invention relates to a process for preparing alpha-hydroxycarboxylic esters from the alcoholysis of alpha-hydroxycarboxam ides in the gas phase, characterized in that the conversion is effected in the presence of water.