19352-70-6

Usage

Chemical structure

1,3,3,4-tetraphenylazetidin-2-one is a chemical compound with four phenyl groups attached to a central azetidin-2-one ring.

Classification

It is classified as a cyclic amide.

Potential applications

It has been studied for its potential applications in organic synthesis and pharmaceutical research.

Building block

It can be used as a building block for the synthesis of new organic compounds.

Drug candidate

It has potential as a drug candidate due to its structural features.

Unique molecular structure

Its unique molecular structure makes it a subject of interest in the field of organic chemistry.

Potential reactivity

Its potential reactivity is of interest in the field of drug development.

Upstream product

• 538-51-2 benzylidene phenylamine 
• 525-06-4 diphenyl ketene 
• 1750-36-3 (E)-N-benzylidenebenzenamine 
• 3469-17-8 2-diazo-1,2-diphenylethan-1-one 
• 1871-76-7 diphenylacetic acid chloride 
• 134-81-6 benzil 

Downstream Products

• 827601-60-5 3-anilino-2,2,3-triphenyl-propionic acid 
• 117-34-0 2,2-diphenylacetic acid 
• 100-52-7 benzaldehyde 
• 62-53-3 aniline 
• 538-51-2 benzylidene phenylamine 
• 530-48-3 1,1-Diphenylethylene 
• 58-72-0 Triphenylethylene 
• 103-71-9 phenyl isocyanate 

Relevant academic research and scientific papers

Photoredox Catalytic Phosphite-Mediated Deoxygenation of α-Diketones Enables Wolff Rearrangement and Staudinger Synthesis of β-Lactams

A novel visible-light-driven catalytic activation of C=O bonds by exploiting the photoredox chemistry of 1,3,2-dioxaphospholes, readily accessible from α-diketones and trialkyl phosphites, is reported. This mild and environmentally friendly strategy provides an unprecedented and efficient access to the Wolff rearrangement reaction which traditionally entails α-diazoketones as precursors. The resulting ketenes could be precisely trapped by alcohols/thiols to give α-aryl (thio)acetates and by imines to afford the valuable β-lactams in up to 99 % yields.

Beta-lactam compound and preparation method thereof

The invention provides a beta-lactam compound and a preparation method thereof. The preparation method comprises the steps of (1) adding a diaryl 1, 2-diketone compound, an imine compound, trialkyl phosphite and a photocatalyst into a reaction vessel, and adding a solvent for dissolving, and carrying out degassing protection on the reaction solution by using argon Ar or nitrogen; (2) irradiating the reaction solution by using a light source and stirring until the reaction is complete; and (3) after the reaction is completed, recovering the solvent under reduced pressure and purifying by column chromatography to obtain the beta-lactam compound. According to the synthesis method of the beta-lactam compound provided by the invention, the substrate range of Staudinger synthesis is expanded, and the synthesis steps are greatly simplified.