193544-97-7Relevant academic research and scientific papers
1,5-Diarylsubstituted 1,2,3-triazoles as potassium channel activators. VI
Biagi, Giuliana,Calderone, Vincenzo,Giorgi, Irene,Livi, Oreste,Martinotti, Enrica,Martelli, Alma,Nardi, Antonio
, p. 397 - 404 (2007/10/03)
As part of our program toward designing potassium channel openers, synthesis of a novel series of 1,5-diphenylsubstituted 1,2,3-triazoles, as potential activators of the large-conductance calcium-activated potassium channels (BK), as well as their vasorel
Synthesis of New 1,2,3-Triazolo[1,2-a]benzotriazole Derivatives or Substituted 2,3-Benzo-13a,6,6a-tetraazapentalenes. II
Biagi, Giuliana,Giorgi, Irene,Livi, Oreste,Manera, Clementina,Scartoni, Valerio,Barili, Pier Luigi
, p. 845 - 851 (2007/10/03)
This paper continues the synthesis of new 1,2,3-triazolo[1,2-a]benzotriazoles or 2,3-benzo-1,3a,6,6a-tetrazapentalenes to submit to biological assays. The derivatives were obtained by deoxycyclization reactions of appropriate nitrophenyl-1,2,3-triazole derivatives and by thermal decomposition of appropriate azidophenyl-1,2,3-triazoles (Schemes 1 and 2). Some attempts to extend these synthetic routes to the preparation of 1,2,4-triazolo[1,2-a]benzotriazoles (Scheme 3) and 1,2,3-triazolo[1,2-b]-4H-1,2,3-benzo-triazines (Scheme 4) completely failed.
