193552-15-7Relevant academic research and scientific papers
α-methylene-γ-butyrolactones: new inhibitors of platelet aggregation
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, (2008/06/13)
The present inventors have discovered three classes of novel α-methylene-γ-butyrolactones with excellent antiplatelet activity. As a result of intensive studies, it has been found that compounds represented by the formula I-III are potent inhibitors of platelet aggregation. STR1 For the formula I, R1 is a methyl, a phenyl group optionally substituted with one or two group selected from halide, (C1 -C4) alkyl, (C1 -C4) alkoxy, phenyl, nitro, amino. For the formula II, R1 is a methyl, a phenyl group optionally substituted with one or two group selected from halide, (C1 -C4) alkyl, (C1 -C4) alkoxy, phenyl, nitro, amino; R2 represents hydrogen, halide, (C1 -C4) alkyl, phenyl, nitro, amino; R3 represents hydrogen, halide, (C1 -C4) alkyl, phenyl, nitro, amino. For the formula III, R1 is a methyl, a phenyl group optionally substituted with one or two group selected from halide, (C1 -C4) alkyl, (C1 -C4) alkoxy, phenyl, nitro, amino; R4 represents hydrogen, hydroxy, (C1 -C4) alkyl. The present invention also provides a cost-efficient method for the preparation of formula I-III. Formula I-III may be administered orally or parenterly with an inert diluent or with a pharmaceutically acceptable carrier in the treatment or the prevention of cardiovascular disease.
Synthesis and antiplatelet evaluation of α-methylene-γ-butyrolactone bearing 2-methylquinoline and 8-hydroxyquinoline moieties
Liou, Shorong-Shii,Zhao, Yue-Ling,Chang, Ya-Ling,Teng, Che-Ming,Tzeng, Cherng-Chyi
, p. 1777 - 1781 (2007/10/03)
In a search for inhibitors of platelet aggregation, some α-methylene- γ-butyrolactones bearing 2-methylquinoline and 8-hydroxyqninoline moieties were synthesized and evaluated for antiplatelet activities against thrombin (Thr)-, arachidonic acid (AA)-, co
