193557-58-3

Upstream product

• 5392-10-9 2-bromo-4,5-dimethoxybenzaldehyde 
• 143-33-9 sodium cyanide 
• 506-59-2 N,N-dimethylammonium chloride 
• 120-14-9 3,4-dimethoxy-benzaldehyde 

Downstream Products

• 299215-69-3 (E)-1,2-bis(2-bromo-4,5-dimethoxyphenyl)-N,N-dimethylethenylamine 
• 299215-73-9 (E)-1-(2-bromo-4,5-dimethoxyphenyl)-2-(2-bromophenyl)-N,N-dimethylethenylamine 
• 96756-82-0 2-bromo-4,5-dimethoxybenzyl 2-bromo-4,5-dimethoxyphenyl ketone 
• 299215-90-0 1-(2-bromo-4,5-dimethoxyphenyl)-2-(2-bromophenyl)ethanone 
• 299216-02-7 4-(2-bromophenyl)-5-(2-bromo-4,5-dimethoxyphenyl)isoxazole 
• 299216-00-5 4,5-bis(2-bromo-4,5-dimethoxyphenyl)isoxazole 

Relevant academic research and scientific papers

2-(2-Bromo-4,5-dimethoxyphenyl)-2-(dimethylamino)acetonitrile

The regioselective synthesis, spectrometric data (1 H and 13 C NMR, and MS) and the X-ray crystal structure determination of the title compound, C12H15BrN2O2, are reported. In spite of the presence of a Br atom ortho to the bulky α-aminonitrile group, normal molecular dimensions have been found.

A Convenient Strategy for the Synthesis of 4,5-Bis(o-haloaryl)isoxazoles

A series of new 1,2-bis(o-haloaryl)ethanones is efficiently prepared and applied to the synthesis of 4,5-bis(o-haloaryl)isoxazoles. Isolation of intermediate hydroxyisoxazolines, which are structurally examined, provides a definitive proof for a heterocyclization mechanism based on an amine exchange process. The isolation and X-ray crystallographic studies of significant side products such as benzamides and triarylpropionitriles are also described.