25623-56-7

Upstream product

• 28732-13-0 3-methylthio-5-(2-aminophenyl)-1,2,4-triazin-5-one 
• 10065-23-3 2-(2-oxoindolin-3-ylidene)hydrazinecarboxamide 
• 91-56-5 indole-2,3-dione 

Downstream Products

• 193603-10-0 6-(2-oximinoacetylaminophenyl)-2,3,4,5-tetrahydro-1,2,4-triazine-3,5-dione 
• 24838-20-8 2H,5H-1,2,4-triazino<5,6-b>indole-3-one 
• 193603-13-3 2,6-bis(3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-yl)-aniline 

Relevant academic research and scientific papers

Development of Novel Oxotriazinoindole Inhibitors of Aldose Reductase: Isosteric Sulfur/Oxygen Replacement in the Thioxotriazinoindole Cemtirestat Markedly Improved Inhibition Selectivity

Inhibition of aldose reductase (AR), the first enzyme of the polyol pathway, is a promising approach in treatment of diabetic complications. We proceeded with optimization of the thioxotriazinoindole scaffold of the novel AR inhibitor cemtirestat by repla

SEMICARBAZONES AND THIOSEMICARBAZONES OF THE HETEROCYCLIC SERIES LIV. DERIVATIVES OF 1,2,4-TRIAZINE, 1,2,4-TRIAZOLE, AND 1,3,4-THIADIAZOLE FROM 1-ACETYL-5-BROMOISATIN AND THIOSEMICARBAZIDE

The reaction of 1-acetyl-5-bromoisatin with thiosemicarbazide and the transformations of the products of this reaction have special features due to the introduction of the bromine atom into the indole ring.In alcohol the reaction leads to the formation of