193673-40-4Relevant academic research and scientific papers
Synthesis of quinolin-4-yl substituted malonates, cyanoacetates, acetoacetates and related compounds
Stadlbauer, Wolfgang,T?ubl, Anna E.,Dang, Hoai V.,Reidlinger, Claudia,Zangger, Klaus
, p. 117 - 125 (2006)
4-Chloro- or 4-tosyloxyquinolines 1 and 10 react with CH-acidic compounds such as malonates 2a,b, ethyl cyanoacetate (2c), malononitrile (2d), ethyl acetoacetate (2e), acetylacetone (2f) or dimedone (2g) under mild conditions and good yields to quinolin-4
Thermal Reactions of 2-(2-Oxo-3-nitro-4-quinolinyl)malonates
Elisabeth Taeubl,Stadlbauer, Wolfgang
, p. 989 - 991 (2007/10/03)
Depending on the ester substituent, diethyl 2-(3-nitro-2-oxo-4-quinolinyl)malonates 2 give upon thermolysis ethyl 2-(3-nitro-2-oxo-4-quinolinyl)acetates 4, whereas dimethyl 2-(3-nitro-2-oxo-4-quinolinyl)-malonates 3 cyclize to give 1-methoxycarbonylisoxazolo[3,4-c]quinolin-4(5H)-ones 5. The necessary reaction conditions can be obtained easily with the help of differential scanning calorimetry.
