193686-18-9

Upstream product

• 2503-32-4 ethyl N-(benzyloxycarbonyl)-L-alanylglycinate 
• 4526-77-6 (S)-3-methyl-2,5-piperazinedione 
• 66959-35-1 ethyl L-alanylglycinate 
• 74124-56-4 (3S)-1,4-diacetyl-3-methylpiperazine-2,5-dione 
• 824-94-2 p-methoxybenzyl chloride 
• 193686-17-8 (6S,3Z)-1-acetyl-4-(4-methoxybenzyl)-6-methyl-3-(2,4,5-trimethoxy-3-methylbenzylidene)piperazine-2,5-dione 

Downstream Products

• 193686-36-1 (6S,3Z)-4-(4-methoxybenzyl)-1,6-dimethyl-3-(2,4,5-trimethoxy-3-methylbenzylidene)piperazine-2,5-dione 

Relevant academic research and scientific papers

Preparation of chiral right-half models of antitumor bistetrahydroisoquinolinequinone natural products

– The preparation of chiral right-half model compounds of bistetrahydroisoquinolinequinone natural products having a lactam carbonyl group (-)-1 or an aminonitrile group (+)-2 from (-)-14 was presented. The crucial steps of this synthesis include the N-methylation of compound (-)-12 and ring closure to generate (-)-19a without any epimerization at C-2.1

Synthesis of novel octahydro-1,5-imino-3-benzazocin-4,7,10-trione derivatives having a methyl group at the C-2 position as ABC ring models of saframycins

(Z)-3-(2,4,5-Trimethoxy-3-methylbenzylidene)-1,6-dimethylpiperazine- 2,5-dione (7a) was prepared by a simple regioselective C-monomethylation of (Z)-4-(4-methoxybenzyl)-3-(2,4,5-trimethoxy-3-methylbenzylidene)-1- methylpiperazine-2,5-dione (3) followed by deprotection. Compound 7a was also prepared from (S)-1,4-diacetyl-3-methylpiperazine-2,5-dione (8) and the benzaldehyde derivative (9) in five steps as an optically active form. It was shown to be a useful intermediate for the preparation of novel octahydro- 1,5-imino-3-benzazocin-4,7,10-trione derivatives having a methyl group at the C-2 position, as ABC ring models of saframycins.