193686-73-6Relevant academic research and scientific papers
Practical synthesis of both enantiomers of vasopressin V2 receptor antagonist OPC-41061 using the catalytic asymmetric hydrogenation
Yamashita, Hiroshi,Ohtani, Tadaaki,Morita, Seiji,Otsubo, Kenji,Kan, Keizo,Matsubara, Jun,Kitano, Kazuyoshi,Kawano, Yoshikazu,Uchida, Minoru,Tabusa, Fujio
, p. 123 - 128 (2007/10/03)
The optically active enantiomers of 7-chloro-5-hydroxy-1-[2methyl-4-(2-methylbenzoylamino)benzoyl]-2,3,4,5- tetrahydro-1H-1-benzazepine (OPC-41061, 1) were enantioselectively synthesized. The asymmetric transfer hydrogenation of the ketone (2), which is t
