193743-67-8

Upstream product

• 85260-02-2 2-(2-Oxo-2-phenyl-ethylsulfanyl)-isoindole-1,3-dione 
• 98-86-2 acetophenone 

Downstream Products

• 96745-96-9 trans-2-benzoyl-3,6-dihydro-4,5-dimethyl-2H-thiapyran 1-oxide 
• 96745-95-8 cis-2-benzoyl-3,6-dihydro-4,5-dimethyl-2H-thiapyran 1-oxide 
• 131497-54-6 2-Benzoyl-3,6-dihydro-4,5-dimethyl-2H-thiopyran 1-oxide 

Relevant academic research and scientific papers

α-Oxosulfines: New Generation Methods and Reactivity

α-oxothiophthalimides 2 can be oxidised the corresponding sulfinimides 3 with m-chloroperoxybenzoic acid.Derivatives 3 in the presence of catalytic amount of pyridine generate the α-oxosulfines 4 which can be trapped by diene 5 to give dihydrothiopyranes 6 as mixture of diastereoisomers.The method appears simple and general since alkyl, aryl and hetroaryl substituted thiophthalimides can be fruitfully used.

α-Oxosulfines part 3. Generation and trapping of α-Oxothioaldehyde S- oxides

α-Oxothioaldehyde S-oxides 4a-f can be generated under very mild conditions from the corresponding sulfinyl compounds 3a-f, which in turn are obtained by m-chloroperoxybenzoic acid (MCPBA) oxidation of α- oxothiophthalimides 2a-f. The reactive sulfine intermediates can be trapped as electron-poor dienophiles as well as electron-poor dienes with formation of dihydrothiopyran S-oxides 5a-e or 1,4-oxathiin S-oxides 6a-f, respectively.