193755-80-5

Upstream product

• 98-09-9 benzenesulfonyl chloride 
• 146395-81-5 3-(3,4-dichlorophenyl)-3-[2-(tetrahydropyran-2-yloxy) ethyl]piperidine 
• 17739-45-6 2-(2-bromoethoxy)tetrahydropyran 
• 3218-49-3 3,4-dichloro-benzeneacetonitrile 
• 135936-16-2 α-[2-(Tetrahydropyran-2-yloxy)ethyl]-3,4-dichlorophenyl-acetonitrile 
• 146395-78-0 5-(3,4-dichlorophenyl)-5-[2-(tetrahydropyran-2-yloxy) ethyl]piperidine-2-one 
• 146395-77-9 Ethyl γ-(2-tetrahydropyranyloxyethyl)-γ-cyano-γ-(3,4-dichlorophenyl)butanoate 

Downstream Products

• 193755-81-6 1-(Phenylsulphonyl)-3-(3,4-dichlorophenyl)-3-(2-hydroxyethyl)piperidine 
• 193755-89-4 3-(3,4-Dichlorophenyl)-3-(2-methanesulphonyloxyethyl)-1-phenylsulphonylpiperidine 

Relevant academic research and scientific papers

4-Amino-2-(aryl)-butylbenzamides and their conformationally constrained analogues. Potent antagonists of the human neurokinin-2 (NK2) receptor

A library, evaluating a range of piperazines, piperidines and acyclic amines, as replacements for the 4-hydroxy-4-phenylpiperidine moiety in lead (1b) was prepared. These efforts identified the 4-((N)-benzimidazolone)piperidine analogue (2a) which was further optimised using classical single-compound synthesis to yield the 3-((N)-morpholino)azetidine (2j). Conformationally constrained analogues of (2j), generally offered no potency advantage in this particular series.