193807-60-2

Usage

Uses

MMP-2/MMP-9 Inhibitor II is a potent inhibitor of MMP-2 and MMP-9.

Upstream product

• 1623-93-4 4-diphenylsulfonyl chloride 
• 193807-58-8 ([1,1'-biphenyl]-4-ylsulfonyl)-D-phenylalanine 
• 1469273-31-1 C₂₅H₂₇NO₄S 
• 3081-28-5 D-phenylalanine tert-butyl ester 
• 193810-34-3 (R)-2-(Biphenyl-4-sulfonylamino)-3-phenyl-propionic acid benzyl ester 
• 193810-35-4 (R)-N-Benzyloxy-2-(biphenyl-4-sulfonylamino)-3-phenyl-propionamide 

Relevant academic research and scientific papers

Specific detection and imaging of enzyme activity by signal-amplifiable self-assembling 19Fa MRI probes

Specific turn-on detection of enzyme activities is of fundamental importance in drug discovery research, as well as medical diagnostics. Although magnetic resonance imaging (MRI) is one of the most powerful techniques for noninvasive visualization of enzy

Highly selective and orally active inhibitors of type IV collagenase (MMP-9 and MMP-2): N-sulfonylamino acid derivatives

Various N-sulfonylamino acid derivatives were synthesized and evaluated for their in vitro and in vivo activities to inhibit type IV collagenase (MMP-9 and MMP-2). When the amino acid residue and the sulfonamide moiety were modified, their inhibitory activities were greatly affected by the structure of the sulfonamide moiety. A series of aryl sulfonamide derivatives containing biaryl, tetrazole, amide, and triple bond were found to be potent and highly selective inhibitors of MMP-9 and MMP-2. In addition, these compounds were orally active in animal models of tumor growth and metastasis. These results revealed the potential of the N-sulfonylamino acid derivatives as a new type of candidate drug for the treatment of cancer.