193810-34-3

Basic information

• Product Name: D-Phenylalanine, N-([1,1'-biphenyl]-4-ylsulfonyl)-, phenylmethyl ester
• CAS NO: 193810-34-3
• Molecular Formula: C28H25NO4S
• Molecular Weight: 471.577
• Mol File: 193810-34-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: D-Phenylalanine, N-([1,1'-biphenyl]-4-ylsulfonyl)-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: D-Phenylalanine, N-([1,1'-biphenyl]-4-ylsulfonyl)-, phenylmethyl ester(193810-34-3)
• EPA Substance Registry System: D-Phenylalanine, N-([1,1'-biphenyl]-4-ylsulfonyl)-, phenylmethyl ester(193810-34-3)

Safety Data

• Hazardous Substances Data: 193810-34-3(Hazardous Substances Data)

Upstream product

• 1623-93-4 4-diphenylsulfonyl chloride 
• 28607-46-7 (R)-phenylalanine benzyl ester p-toluenosulfonate 

Downstream Products

• 193810-35-4 (R)-N-Benzyloxy-2-(biphenyl-4-sulfonylamino)-3-phenyl-propionamide 
• 193807-60-2 (2R)-[(4-biphenylylsulfonyl)amino]-N-hydroxy-3-phenylpropionamide 
• 193807-58-8 ([1,1'-biphenyl]-4-ylsulfonyl)-D-phenylalanine 

Relevant articles and documents

Highly selective and orally active inhibitors of type IV collagenase (MMP-9 and MMP-2): N-sulfonylamino acid derivatives

Various N-sulfonylamino acid derivatives were synthesized and evaluated for their in vitro and in vivo activities to inhibit type IV collagenase (MMP-9 and MMP-2). When the amino acid residue and the sulfonamide moiety were modified, their inhibitory activities were greatly affected by the structure of the sulfonamide moiety. A series of aryl sulfonamide derivatives containing biaryl, tetrazole, amide, and triple bond were found to be potent and highly selective inhibitors of MMP-9 and MMP-2. In addition, these compounds were orally active in animal models of tumor growth and metastasis. These results revealed the potential of the N-sulfonylamino acid derivatives as a new type of candidate drug for the treatment of cancer.