193882-51-8

Upstream product

• 117992-75-3 2-{2-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-ethyl}-isoindole-1,3-dione 
• 39512-49-7 4-(4-chlorophenyl)-4-hydroxypiperidine 

Relevant academic research and scientific papers

Synthesis and pharmacological activity of 2-(substituted phenyl)-3{2 or 3-[(4-substituted phenyl-4-hydroxy)piperidino]ethyl or propyl}-1,3- thiazolidin-4-ones

A series of aryl-hydroxy-piperidinoalkyl-thiazolidinones was synthesized and evaluated to inhibit castor oil-induced diarrhea in mice. The dose dependent antidiarrheal activity of the most active compound 2-(p- nitrophenyl)-3-[2-[(4-(p-chlorophenyl)-4-hydroxy)piperidino]ethyl]-1,3- thiazolidin-4-one (6) was counteracted by naloxone, resulting comparable with that of loperamide, a μ opiate agonist.